Vitamin D in Individuals Before Onset of Rheumatoid Arthritis - Relation to Vitamin D Binding Protein and Its Associated Genetic Variants

Overview

Journal BMC Rheumatol

Specialty Rheumatology

Date 2019 Mar 20

PMID 30886976

Citations 10

Authors

Mikael Brink

Linda Johansson

Evelina Nygren

Lisbeth Arlestig

Johan Hultdin

Solbritt Rantapaa-Dahlqvist

Affiliations

Soon will be listed here.

Abstract

Background: Vitamin D has been implicated as being involved in the aetio-pathogenesis of several autoimmune diseases including rheumatoid arthritis (RA). Previous studies present contradictory results. Vitamin D binding protein (DBP), the major transport protein, is also involved in various inflammatory processes. The aim of this study was to investigate the relationship between circulating levels of 25-hydroxyvitamin D [25(OH) D], DBP and polymorphisms in group-specific component (GC) in pre-symptomatic individuals and matched controls within prospective cohorts of the Northern Sweden.

Methods: Blood samples donated to the Medical Biobank prior to the onset of symptoms of RA ( = 515, mean [SD] time before the onset of symptoms 6.2 [9.3] years) and from matched (2:1) population-based controls ( = 267) were used. Plasma 25(OH) vitamin D levels were analyzed using liquid chromatography tandem-mass spectrometry and DBP levels were analyzed using enzyme-linked immunosorbent assay. GC polymorphisms (rs4588 and rs7041) were analyzed with TaqMan assays (Applied Biosystems).

Results: Levels of 25(OH) D or DBP were not statistically different between pre-symptomatic individuals and controls in a crude, or a multiple-adjusted logistic regression model. However, an increased risk for future RA was found in females of DBP (OR 1.014 [95%CI 1.001-1.028]) per 10 mg/L adjusted for carriage of the minor allele of rs4588, in a multiple-adjusted model ( < 0.05).

Conclusions: This study indicated that vitamin D is not associated with the future risk of RA although increasing levels of DBP were however, associated with an increased risk of disease in females carrying the minor allele of a DBP encoding SNP.

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References

DeLuca H, Cantorna M . Vitamin D: its role and uses in immunology. FASEB J. 2001; 15(14):2579-85. DOI: 10.1096/fj.01-0433rev. View

Rantapaa-Dahlqvist S, de Jong B, Berglin E, Hallmans G, Wadell G, Stenlund H . Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 2003; 48(10):2741-9. DOI: 10.1002/art.11223. View

Merlino L, Curtis J, Mikuls T, Cerhan J, Criswell L, Saag K . Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study. Arthritis Rheum. 2004; 50(1):72-7. DOI: 10.1002/art.11434. View

Lauridsen A, Vestergaard P, Hermann A, Brot C, Heickendorff L, Mosekilde L . Plasma concentrations of 25-hydroxy-vitamin D and 1,25-dihydroxy-vitamin D are related to the phenotype of Gc (vitamin D-binding protein): a cross-sectional study on 595 early postmenopausal women. Calcif Tissue Int. 2005; 77(1):15-22. DOI: 10.1007/s00223-004-0227-5. View

Nielen M, van Schaardenburg D, Lems W, van de Stadt R, de Koning M, Reesink H . Vitamin D deficiency does not increase the risk of rheumatoid arthritis: comment on the article by Merlino et al. Arthritis Rheum. 2006; 54(11):3719-20. DOI: 10.1002/art.22191. View

Cutolo M, Otsa K, Laas K, Yprus M, Lehtme R, Secchi M . Circannual vitamin d serum levels and disease activity in rheumatoid arthritis: Northern versus Southern Europe. Clin Exp Rheumatol. 2007; 24(6):702-4. View

Bolland M, Grey A, Ames R, Horne A, Mason B, Wattie D . Age-, gender-, and weight-related effects on levels of 25-hydroxyvitamin D are not mediated by vitamin D binding protein. Clin Endocrinol (Oxf). 2007; 67(2):259-64. DOI: 10.1111/j.1365-2265.2007.02873.x. View

Arnson Y, Amital H, Shoenfeld Y . Vitamin D and autoimmunity: new aetiological and therapeutic considerations. Ann Rheum Dis. 2007; 66(9):1137-42. PMC: 1955167. DOI: 10.1136/ard.2007.069831. View

Costenbader K, Feskanich D, Holmes M, Karlson E, Benito-Garcia E . Vitamin D intake and risks of systemic lupus erythematosus and rheumatoid arthritis in women. Ann Rheum Dis. 2007; 67(4):530-5. PMC: 2717608. DOI: 10.1136/ard.2007.072736. View

10.

Zerwekh J . Blood biomarkers of vitamin D status. Am J Clin Nutr. 2008; 87(4):1087S-91S. DOI: 10.1093/ajcn/87.4.1087S. View

11.

Sinotte M, Diorio C, Berube S, Pollak M, Brisson J . Genetic polymorphisms of the vitamin D binding protein and plasma concentrations of 25-hydroxyvitamin D in premenopausal women. Am J Clin Nutr. 2009; 89(2):634-40. DOI: 10.3945/ajcn.2008.26445. View

12.

Klareskog L, Catrina A, Paget S . Rheumatoid arthritis. Lancet. 2009; 373(9664):659-72. DOI: 10.1016/S0140-6736(09)60008-8. View

13.

Feser M, Derber L, Deane K, Lezotte D, Weisman M, Buckner J . Plasma 25,OH vitamin D concentrations are not associated with rheumatoid arthritis (RA)-related autoantibodies in individuals at elevated risk for RA. J Rheumatol. 2009; 36(5):943-6. PMC: 2745328. DOI: 10.3899/jrheum.080764. View

14.

McGrath J, Saha S, Burne T, Eyles D . A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations. J Steroid Biochem Mol Biol. 2010; 121(1-2):471-7. DOI: 10.1016/j.jsbmb.2010.03.073. View

15.

Wang T, Zhang F, Richards J, Kestenbaum B, van Meurs J, Berry D . Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet. 2010; 376(9736):180-8. PMC: 3086761. DOI: 10.1016/S0140-6736(10)60588-0. View

16.

Snellman G, Melhus H, Gedeborg R, Byberg L, Berglund L, Wernroth L . Determining vitamin D status: a comparison between commercially available assays. PLoS One. 2010; 5(7):e11555. PMC: 2903481. DOI: 10.1371/journal.pone.0011555. View

17.

Lai J, Lucas R, Banks E, Ponsonby A . Variability in vitamin D assays impairs clinical assessment of vitamin D status. Intern Med J. 2011; 42(1):43-50. DOI: 10.1111/j.1445-5994.2011.02471.x. View

18.

Powe C, Ricciardi C, Berg A, Erdenesanaa D, Collerone G, Ankers E . Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship. J Bone Miner Res. 2011; 26(7):1609-16. PMC: 3351032. DOI: 10.1002/jbmr.387. View

19.

Gozdzik A, Zhu J, Wong B, Fu L, Cole D, Parra E . Association of vitamin D binding protein (VDBP) polymorphisms and serum 25(OH)D concentrations in a sample of young Canadian adults of different ancestry. J Steroid Biochem Mol Biol. 2011; 127(3-5):405-12. DOI: 10.1016/j.jsbmb.2011.05.009. View

20.

Humphreys K, Grankvist A, Leu M, Hall P, Liu J, Ripatti S . The genetic structure of the Swedish population. PLoS One. 2011; 6(8):e22547. PMC: 3150368. DOI: 10.1371/journal.pone.0022547. View