Plasma 25,OH Vitamin D Concentrations Are Not Associated with Rheumatoid Arthritis (RA)-related Autoantibodies in Individuals at Elevated Risk for RA

Overview

Journal J Rheumatol

Specialty Rheumatology

Date 2009 Mar 17

PMID 19286844

Citations 26

Authors

Marie Feser

Lezlie A Derber

Kevin D Deane

Dennis C Lezotte

Michael H Weisman

Jane H Buckner

Ted Mikuls

James ODell

Peter K Gregersen

V Michael Holers

Jill M Norris

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the association between rheumatoid arthritis (RA)-related autoantibodies and plasma 25,OH vitamin D in subjects at risk for RA.

Methods: In 1210 subjects without RA, 76 were positive for anti-cyclic citrullinated peptide antibodies or for at least 2 rheumatoid factors (RF; by nephelometry: RF-IgM, RF-IgG, RF-IgA). 25,OH vitamin D was measured in these cases and 154 autoantibody-negative controls from this cohort.

Results: 25,OH vitamin D levels did not differ between cases and controls (adjusted OR 1.23, 95% CI 0.93-1.63).

Conclusion: Vitamin D concentrations are not associated with RA-related autoimmunity in unaffected subjects at increased risk for RA.

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