High Serum Concentration of Vitamin D May Protect Against Multiple Sclerosis

Overview

Journal Mult Scler J Exp Transl Clin

Date 2019 Dec 17

PMID 31839980

Citations 9

Authors

Martin Bistrom

Lucia Alonso-Magdalena

Oluf Andersen

Daniel Jons

Martin Gunnarsson

Magnus Vrethem

Johan Hultdin

Peter Sundstrom

Affiliations

Soon will be listed here.

Abstract

Background: High 25-hydroxyvitamin D concentrations have been associated with a reduced risk of multiple sclerosis, with indications of a stronger effect among young individuals.

Objective: Investigate the 25-hydroxyvitamin D association with multiple sclerosis and test if this association is age dependent.

Methods: Prospectively drawn blood samples from individuals later developing relapsing-remitting multiple sclerosis and controls matched for biobank, sex, age and date of sampling, were analysed with liquid chromatography tandem mass spectrometry.

Results: High levels of 25-hydroxyvitamin D (top quintile) were associated with a reduced multiple sclerosis risk (odds ratio 0.68, 95% confidence interval 0.50-0.93).

Conclusion: These findings further support a role for vitamin D in MS aetiology.

Citing Articles

Potential pathogenic and protective genotypes and phenotypes of vitamin D binding protein in multiple sclerosis.

Al-Shammri S, Chattopadhyay A, Mustafa A Front Neurol. 2025; 16:1455779.

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Rubella virus seropositivity after infection or vaccination as a risk factor for multiple sclerosis.

Ingvarsson J, Grut V, Bistrom M, Berg L, Stridh P, Huang J Eur J Neurol. 2024; 31(10):e16387.

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Human herpesvirus 6A and axonal injury before the clinical onset of multiple sclerosis.

Grut V, Bistrom M, Salzer J, Stridh P, Jons D, Gustafsson R Brain. 2023; 147(1):177-185.

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Seroreactivity against lytic, latent and possible cross-reactive EBV antigens appears on average 10 years before MS induced preclinical neuroaxonal damage.

Jons D, Grut V, Bergstrom T, Zetterberg H, Bistrom M, Gunnarsson M J Neurol Neurosurg Psychiatry. 2023; 95(4):325-332.

PMID: 37802637 PMC: 10958269. DOI: 10.1136/jnnp-2023-331868.

Systemic inflammation and risk of multiple sclerosis - A presymptomatic case-control study.

Grut V, Bistrom M, Salzer J, Stridh P, Lindam A, Alonso-Magdalena L Mult Scler J Exp Transl Clin. 2022; 8(4):20552173221139768.

PMID: 36440320 PMC: 9685111. DOI: 10.1177/20552173221139768.

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