Efficacy of Dental Local Anesthetics: A Review

Overview

Journal J Dent Anesth Pain Med

Date 2019 Jan 15

PMID 30637342

Citations 9

Authors

Nelly Badr

Johan Aps

Affiliations

Soon will be listed here.

Abstract

The objective of this review was to investigate the efficacy of dental local anesthetics, as it is well known among clinicians that local anesthesia may be challenging in some circumstances. Therefore, the focus of this review was on the efficacy of the products used in dental local anesthesia. In a Pubmed database literature search conducted, a total of 8646 articles were found to be related to dental local anesthetics. After having applied the inclusion criteria (human research, performed in the last 10 years, written in English language, and focus on dental local anesthetics) and having assessed the quality of the papers, 30 were deemed eligible for inclusion in this review. The conclusion of this review is that none of the dental local anesthetic amides provide 100% anesthesia. The problem appears to be more pronounced when mandibular teeth are attempted to be anaesthetized and especially if there is irreversible pulpitis involved. The authors conclude that this finding suggest exploration of more efficient techniques to administer dental local anesthesia, especially in the mandible, to establish a 100% efficacy, is needed.

Citing Articles

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References

Nakai Y, Milgrom P, Mancl L, Coldwell S, Domoto P, Ramsay D . Effectiveness of local anesthesia in pediatric dental practice. J Am Dent Assoc. 2001; 131(12):1699-705. DOI: 10.14219/jada.archive.2000.0115. View

Sanchis J, Penarrocha M, Soler F . Bifid mandibular canal. J Oral Maxillofac Surg. 2003; 61(4):422-4. DOI: 10.1053/joms.2003.50004. View

Colombini B, Modena K, Calvo A, Sakai V, Giglio F, Dionisio T . Articaine and mepivacaine efficacy in postoperative analgesia for lower third molar removal: a double-blind, randomized, crossover study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 102(2):169-74. DOI: 10.1016/j.tripleo.2005.09.003. View

Goodman A, Reader A, Nusstein J, Beck M, Weaver J . Anesthetic efficacy of lidocaine/meperidine for inferior alveolar nerve blocks. Anesth Prog. 2006; 53(4):131-9. PMC: 1705828. DOI: 10.2344/0003-3006(2006)53[131:AEOMFI]2.0.CO;2. View

Brkovic B, Gardasevic M, Roganovic J, Jovic N, Todorovic L, Stojic D . Lidocaine+clonidine for maxillary infiltration anaesthesia: parameters of anaesthesia and vascular effects. Int J Oral Maxillofac Surg. 2007; 37(2):149-55. DOI: 10.1016/j.ijom.2007.07.019. View

Evans G, Nusstein J, Drum M, Reader A, Beck M . A prospective, randomized, double-blind comparison of articaine and lidocaine for maxillary infiltrations. J Endod. 2008; 34(4):389-93. DOI: 10.1016/j.joen.2008.01.004. View

Brunetto P, Ranali J, Ambrosano G, de Oliveira P, Groppo F, Meechan J . Anesthetic efficacy of 3 volumes of lidocaine with epinephrine in maxillary infiltration anesthesia. Anesth Prog. 2008; 55(2):29-34. PMC: 2424013. DOI: 10.2344/0003-3006(2008)55[29:AEOVOL]2.0.CO;2. View

Srinivasan N, Kavitha M, Loganathan C, Padmini G . Comparison of anesthetic efficacy of 4% articaine and 2% lidocaine for maxillary buccal infiltration in patients with irreversible pulpitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008; 107(1):133-6. DOI: 10.1016/j.tripleo.2008.09.002. View

Perez-Castro R, Patel S, Garavito-Aguilar Z, Rosenberg A, Recio-Pinto E, Zhang J . Cytotoxicity of local anesthetics in human neuronal cells. Anesth Analg. 2009; 108(3):997-1007. DOI: 10.1213/ane.0b013e31819385e1. View

10.

Mason R, Drum M, Reader A, Nusstein J, Beck M . A prospective, randomized, double-blind comparison of 2% lidocaine with 1:100,000 and 1:50,000 epinephrine and 3% mepivacaine for maxillary infiltrations. J Endod. 2009; 35(9):1173-7. DOI: 10.1016/j.joen.2009.06.016. View

11.

Berberich G, Reader A, Drum M, Nusstein J, Beck M . A prospective, randomized, double-blind comparison of the anesthetic efficacy of two percent lidocaine with 1:100,000 and 1:50,000 epinephrine and three percent mepivacaine in the intraoral, infraorbital nerve block. J Endod. 2009; 35(11):1498-504. DOI: 10.1016/j.joen.2009.08.007. View

12.

Brkovic B, Zlatkovic M, Jovanovic D, Stojic D . Maxillary infiltration anaesthesia by ropivacaine for upper third molar surgery. Int J Oral Maxillofac Surg. 2009; 39(1):36-41. DOI: 10.1016/j.ijom.2009.11.009. View

13.

Katyal V . The efficacy and safety of articaine versus lignocaine in dental treatments: a meta-analysis. J Dent. 2009; 38(4):307-17. DOI: 10.1016/j.jdent.2009.12.003. View

14.

Whitcomb M, Drum M, Reader A, Nusstein J, Beck M . A prospective, randomized, double-blind study of the anesthetic efficacy of sodium bicarbonate buffered 2% lidocaine with 1:100,000 epinephrine in inferior alveolar nerve blocks. Anesth Prog. 2010; 57(2):59-66. PMC: 2886919. DOI: 10.2344/0003-3006-57.2.59. View

15.

Garisto G, Gaffen A, Lawrence H, Tenenbaum H, Haas D . Occurrence of paresthesia after dental local anesthetic administration in the United States. J Am Dent Assoc. 2010; 141(7):836-44. DOI: 10.14219/jada.archive.2010.0281. View

16.

Wali M, Drum M, Reader A, Nusstein J . Prospective, randomized single-blind study of the anesthetic efficacy of 1.8 and 3.6 milliliters of 2% lidocaine with 1:50,000 epinephrine for inferior alveolar nerve block. J Endod. 2010; 36(9):1459-62. DOI: 10.1016/j.joen.2010.05.012. View

17.

Forloine A, Drum M, Reader A, Nusstein J, Beck M . A prospective, randomized, double-blind comparison of the anesthetic efficacy of two percent lidocaine with 1:100,000 epinephrine and three percent mepivacaine in the maxillary high tuberosity second division nerve block. J Endod. 2010; 36(11):1770-7. DOI: 10.1016/j.joen.2010.08.014. View

18.

Lawaty I, Drum M, Reader A, Nusstein J . A prospective, randomized, double-blind comparison of 2% mepivacaine with 1 : 20,000 levonordefrin versus 2% lidocaine with 1 : 100,000 epinephrine for maxillary infiltrations. Anesth Prog. 2010; 57(4):139-44. PMC: 3006661. DOI: 10.2344/0003-3006-57.4.139. View

19.

McEntire M, Nusstein J, Drum M, Reader A, Beck M . Anesthetic efficacy of 4% Articaine with 1:100,000 epinephrine versus 4% articaine with 1:200,000 epinephrine as a primary buccal infiltration in the mandibular first molar. J Endod. 2011; 37(4):450-4. DOI: 10.1016/j.joen.2010.12.007. View

20.

Krzeminski T, Gilowski L, Wiench R, Plocica I, Kondzielnik P, Sielanczyk A . Comparison of ropivacaine and articaine with epinephrine for infiltration anaesthesia in dentistry - a randomized study. Int Endod J. 2011; 44(8):746-51. DOI: 10.1111/j.1365-2591.2011.01881.x. View