A Microtube Array Membrane (MTAM) Encapsulated Live Fermenting Staphylococcus Epidermidis As a Skin Probiotic Patch Against Cutibacterium Acnes

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2018 Dec 23

PMID 30577530

Citations 19

Authors

Albert-Jackson Yang

Shinta Marito

John-Jackson Yang

Sunita Keshari

Chee-Ho Chew

Chien-Chung Chen

Chun-Ming Huang

Affiliations

Soon will be listed here.

Abstract

Antibiotics without selectivity for acne treatment may destroy the beneficial microbes in the human microbiome that helps to fight Cutibacterium acnes (C. acnes), a bacterium associated with inflammatory acne vulgaris. Probiotic treatment by direct application of live () onto the open acne lesions may run the risk of bloodstream infections. Here, we fabricated the polysulfone microtube array membranes (PSF MTAM) to encapsulate probiotic We demonstrate that the application of the encapsulation of in PSF MTAM enhanced the glycerol fermentation activities of To mimic the granulomatous type of acne inflammatory acne vulgaris, the ears of mice were injected intradermally with to induce the secretion of macrophage inflammatory protein-2 (MIP-2), a murine counterpart of human interleukin (IL)-8. The C. acnes-injected mouse ears were covered with a PST MTAM encapsulated with or without in the presence of glycerol. The application of -encapsulated PST MTAM plus glycerol onto the -injected mouse ears considerably reduced the growth of and the production of MIP-2. Furthermore, no leaked from PSF MTAM into mouse skin. The -encapsulated PST MTAM functions as a probiotic acne patch.

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