Passive Immunoprotection Targeting a Secreted CAMP Factor of Propionibacterium Acnes As a Novel Immunotherapeutic for Acne Vulgaris

Overview

Journal Vaccine

Specialty Allergy & Immunology

Date 2011 Mar 1

PMID 21354482

Citations 28

Authors

Pei-Feng Liu

Teruaki Nakatsuji

Wenhong Zhu

Richard L Gallo

Chun-Ming Huang

Affiliations

Soon will be listed here.

Abstract

Propionibacterium acnes (P. acnes) bacteria play a key role in the pathogenesis of acne vulgaris. Although our previous studies have demonstrated that vaccines targeting a surface sialidase or bacterial particles exhibit a preventive effect against P. acnes, the lack of therapeutic activities and incapability of neutralizing secretory virulence factors motivate us to generate novel immunotherapeutics. In this study, we develop an immunotherapeutic antibody to secretory Christie-Atkins-Munch-Peterson (CAMP) factor of P. acnes. Via agroinfiltration, P. acnes CAMP factor was encapsulated into the leaves of radishes. ICR mice intranasally immunized with whole leaves expressing CAMP factor successfully produced neutralizing antibodies that efficiently attenuated P. acnes-induced ear swelling and production of macrophage-inflammatory protein-2. Passive neutralization of CAMP factor enhanced immunity to eradicate P. acnes at the infection site without influencing bacterial growth elsewhere. We propose that CAMP factor is a novel therapeutic target for the treatment of various P. acnes-associated diseases and highlight the concept of neutralizing P. acnes virulence without disturbing the bacterial commensalism in human microbiome.

Citing Articles

Vaccines in Dermatology-Present and Future: A Review.

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Characterization of a Camp Factor 1-Related Peptide as a New TLR-2 Modulator in In Vitro and Ex Vivo Models of Inflammation.

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Prediction of Antibacterial Peptides against from the Peptidomes of Mucus Fractions.

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