The Updates and Implications of Cutaneous Microbiota in Acne

Overview

Journal Cell Biosci

Publisher Biomed Central

Specialty Biology

Date 2023 Jun 21

PMID 37344849

Authors

Cong Huang

Fan Zhuo

Baoquan Han

Wenting Li

Bin Jiang

Kaoyuan Zhang

Xingling Jian

Zhenzhen Chen

Hui Li

Haiyan Huang

Xia Dou

Bo Yu

Affiliations

Soon will be listed here.

Abstract

Acne is a chronic inflammatory skin disorder that profoundly impacts the quality of life of patients worldwide. While it is predominantly observed in adolescents, it can affect individuals across all age groups. Acne pathogenesis is believed to be a result of various endogenous and exogenous factors, but the precise mechanisms remain elusive. Recent studies suggest that dysbiosis of the skin microbiota significantly contributes to acne development. Specifically, Cutibacterium acnes, the dominant resident bacterial species implicated in acne, plays a critical role in disease progression. Various treatments, including topical benzoyl peroxide, systemic antibiotics, and photodynamic therapy, have demonstrated beneficial effects on the skin microbiota composition in acne patients. Of particular interest is the therapeutic potential of probiotics in acne, given its direct influence on the skin microbiota. This review summarizes the alterations in skin microbiota associated with acne, provides insight into its pathogenic role in acne, and emphasizes the potential of therapeutic interventions aimed at restoring microbial homeostasis for acne management.

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