AN-9 (Titan)

Overview

Journal Curr Opin Investig Drugs

Specialties Infectious Diseases
Pharmacology

Date 2004 Jul 10

PMID 15242252

Citations 6

Authors

Erole Hobdy

John Murren

Affiliations

Soon will be listed here.

Abstract

Titan is developing AN-9 for the potential treatment of various cancers. AN-9 is a histone deacetylase inhibitor analog of butyric acid that causes apoptosis of cancer cells through signaling cellular differentiation. In March 2001, a phase I/II study involving patients with liver tumors was initiated. By November 2001, enrollment had been completed in a second phase II study of refractory non-small-cell lung cancer (NSCLC). In June 2003, Titan began enrollment for a phase IIb trial of AN-9 in combination with docetaxel in patients with NSCLC.

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