PARP Family Enzymes: Regulation and Catalysis of the Poly(ADP-ribose) Posttranslational Modification

Overview

Journal Curr Opin Struct Biol

Date 2018 Nov 28

PMID 30481609

Citations 95

Authors

Marie-France Langelier

Travis Eisemann

Amanda A Riccio

John M Pascal

Affiliations

Soon will be listed here.

Abstract

Poly(ADP-ribose) is a posttranslational modification and signaling molecule that regulates many aspects of human cell biology, and it is synthesized by enzymes known as poly(ADP-ribose) polymerases, or PARPs. A diverse collection of domain structures dictates the different cellular roles of PARP enzymes and regulates the production of poly(ADP-ribose). Here we primarily review recent structural insights into the regulation and catalysis of two family members: PARP-1 and Tankyrase. PARP-1 has multiple roles in the cellular response to DNA damage and the regulation of gene transcription, and Tankyrase regulates a diverse set of target proteins involved in cellular processes such as mitosis, genome integrity, and cell signaling. Both enzymes offer interesting modes of regulating the production and the target site selectivity of the poly(ADP-ribose) modification.

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