A Ribose-functionalized NAD with Versatile Activity for ADP-ribosylation

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2023 Nov 3

PMID 37921487

Authors

Elisa N Stephens

Xiao-Nan Zhang

Albert T Lam

Jiawei Li

Hua Pei

Stan G Louie

Clay C C Wang

Yong Zhang

Affiliations

Soon will be listed here.

Abstract

An NAD featuring an adenosyl 4'-azido functions as a general substrate for poly-ADP-ribose polymerases. Its derived mono- and poly-ADP-ribosylated proteins can be adequately recognized by distinct ADP-ribosylation-specific readers. This molecule represents the first ribose-functionalized NAD with versatile activities across different ADP-ribosyltransferases and provides insight into developing new probes for ADP-ribosylation.

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