John M Pascal
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Explore the profile of John M Pascal including associated specialties, affiliations and a list of published articles.
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81
Citations
3909
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Recent Articles
1.
Smith-Pillet E, Billur R, Langelier M, Talele T, Pascal J, Black B
Mol Cell
. 2025 Jan;
85(5):865-876.e4.
PMID: 39889708
Poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 recognize DNA breaks immediately upon their formation, generate a burst of local PARylation to signal their location, and are co-targeted by all current FDA-approved...
2.
Cheng S, Gafaar T, Kuttiyatveetil J, Sverzhinsky A, Chen C, Xu M, et al.
Nat Commun
. 2025 Jan;
16(1):621.
PMID: 39805863
Non-covalent interactions of poly(ADP-ribose) (PAR) facilitate condensate formation, yet the impact of these interactions on condensate properties remains unclear. Here, we demonstrate that PAR-mediated interactions through PARP13, specifically the PARP13.2...
3.
Valerie N, Sanjiv K, Mortusewicz O, Zhang S, Alam S, Pires M, et al.
Nat Commun
. 2024 Dec;
15(1):10347.
PMID: 39643609
Cellular target engagement technologies enable quantification of intracellular drug binding; however, simultaneous assessment of drug-associated phenotypes has proven challenging. Here, we present cellular target engagement by accumulation of mutant as...
4.
Langelier M, Mirhasan M, Gilbert K, Sverzhinksy A, Furtos A, Pascal J
Mol Cell
. 2024 Nov;
84(24):4758-4773.e6.
PMID: 39536748
PARP enzymes transfer ADP-ribose from NAD onto proteins as a covalent modification that regulates multiple aspects of cell biology. Here, we identify an undiscovered catalytic activity for human PARP1: de...
5.
Smith-Pillet E, Billur R, Langelier M, Talele T, Pascal J, Black B
bioRxiv
. 2024 Jun;
PMID: 38826291
PARP1 and PARP2 recognize DNA breaks immediately upon their formation, generate a burst of local PARylation to signal their location, and are co-targeted by all current FDA-approved forms of PARP...
6.
Velagapudi U, Rouleau-Turcotte E, Billur R, Shao X, Patil M, Black B, et al.
Biochem J
. 2024 Feb;
481(6):437-460.
PMID: 38372302
Catalytic poly(ADP-ribose) production by PARP1 is allosterically activated through interaction with DNA breaks, and PARP inhibitor compounds have the potential to influence PARP1 allostery in addition to preventing catalytic activity....
7.
Frigon L, Pascal J
Nucleic Acids Res
. 2023 Nov;
51(22):12492-12507.
PMID: 37971310
PARP4 is an ADP-ribosyltransferase that resides within the vault ribonucleoprotein organelle. Our knowledge of PARP4 structure and biochemistry is limited relative to other PARPs. PARP4 shares a region of homology...
8.
Rouleau-Turcotte E, Pascal J
J Biol Chem
. 2023 Oct;
299(12):105397.
PMID: 37898399
ADP-ribose is a versatile modification that plays a critical role in diverse cellular processes. The addition of this modification is catalyzed by ADP-ribosyltransferases, among which notable poly(ADP-ribose) polymerase (PARP) enzymes...
9.
Pascal J
Curr Opin Struct Biol
. 2023 Jun;
81:102643.
PMID: 37352603
PARP enzymes create ADP-ribose modifications to regulate multiple facets of human biology, and some prominent PARP family members are best known for the nucleic acid interactions that regulate their activities...
10.
Langelier M, Lin X, Zha S, Pascal J
Sci Adv
. 2023 Mar;
9(12):eadf7175.
PMID: 36961901
PARP1 and PARP2 detect DNA breaks, which activates their catalytic production of poly(ADP-ribose) that recruits repair factors and contributes to PARP1/2 release from DNA. PARP inhibitors (PARPi) are used in...