Genomics and Transcriptomics of Megakaryocytes and Platelets: Implications for Health and Disease

Overview

Journal Res Pract Thromb Haemost

Publisher Elsevier

Date 2018 Oct 24

PMID 30349880

Citations 11

Authors

Marlie H Fisher

Jorge Di Paola

Affiliations

Soon will be listed here.

Abstract

The field of megakaryocyte and platelet biology has been transformed with the implementation of high throughput sequencing. The use of modern sequencing technologies has led to the discovery of causative mutations in congenital platelet disorders and has been a useful tool in uncovering many other mechanisms of altered platelet formation and function. Although the understanding of the presence of RNA in platelets is relatively novel, mRNA and miRNA expression profiles are being shown to play an increasingly important role in megakaryopoiesis and platelet function in normal physiology as well as in disease states. Understanding the genetic perturbations underlying platelet dysfunction provides insight into normal megakaryopoiesis and thrombopoiesis, as well as guiding the development of novel therapeutics.

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