Emerging Roles for Platelets As Immune and Inflammatory Cells

Overview

Journal Blood

Publisher Elsevier

Specialty Hematology

Date 2014 Mar 4

PMID 24585776

Citations 330

Authors

Craig N Morrell

Angela A Aggrey

Lesley M Chapman

Kristina L Modjeski

Affiliations

Soon will be listed here.

Abstract

Despite their small size and anucleate status, platelets have diverse roles in vascular biology. Not only are platelets the cellular mediator of thrombosis, but platelets are also immune cells that initiate and accelerate many vascular inflammatory conditions. Platelets are linked to the pathogenesis of inflammatory diseases such as atherosclerosis, malaria infection, transplant rejection, and rheumatoid arthritis. In some contexts, platelet immune functions are protective, whereas in others platelets contribute to adverse inflammatory outcomes. In this review, we will discuss platelet and platelet-derived mediator interactions with the innate and acquired arms of the immune system and platelet-vessel wall interactions that drive inflammatory disease. There have been many recent publications indicating both important protective and adverse roles for platelets in infectious disease. Because of this new accumulating data, and the fact that infectious disease continues to be a leading cause of death globally, we will also focus on new and emerging concepts related to platelet immune and inflammatory functions in the context of infectious disease.

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References

Beaulieu L, Lin E, Morin K, Tanriverdi K, Freedman J . Regulatory effects of TLR2 on megakaryocytic cell function. Blood. 2011; 117(22):5963-74. PMC: 3112041. DOI: 10.1182/blood-2010-09-304949. View

Ghosh A, Murugesan G, Chen K, Zhang L, Wang Q, Febbraio M . Platelet CD36 surface expression levels affect functional responses to oxidized LDL and are associated with inheritance of specific genetic polymorphisms. Blood. 2011; 117(23):6355-66. PMC: 3122954. DOI: 10.1182/blood-2011-02-338582. View

Shoji T, Koyama H, Fukumoto S, Maeno T, Yokoyama H, Shinohara K . Platelet-monocyte aggregates are independently associated with occurrence of carotid plaques in type 2 diabetic patients. J Atheroscler Thromb. 2006; 12(6):344-52. DOI: 10.5551/jat.12.344. View

Lopez-Dee Z, Pidcock K, Gutierrez L . Thrombospondin-1: multiple paths to inflammation. Mediators Inflamm. 2011; 2011:296069. PMC: 3134184. DOI: 10.1155/2011/296069. View

Wong C, Jenne C, Petri B, Chrobok N, Kubes P . Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance. Nat Immunol. 2013; 14(8):785-92. PMC: 4972575. DOI: 10.1038/ni.2631. View

Italiano Jr J, Battinelli E . Selective sorting of alpha-granule proteins. J Thromb Haemost. 2009; 7 Suppl 1:173-6. PMC: 3004150. DOI: 10.1111/j.1538-7836.2009.03387.x. View

Dotsenko O, Chaturvedi N, Thom S, Wright A, Mayet J, Shore A . Platelet and leukocyte activation, atherosclerosis and inflammation in European and South Asian men. J Thromb Haemost. 2007; 5(10):2036-42. PMC: 2650817. DOI: 10.1111/j.1538-7836.2007.02711.x. View

Panigrahi S, Ma Y, Hong L, Gao D, West X, Salomon R . Engagement of platelet toll-like receptor 9 by novel endogenous ligands promotes platelet hyperreactivity and thrombosis. Circ Res. 2012; 112(1):103-12. PMC: 3537845. DOI: 10.1161/CIRCRESAHA.112.274241. View

Pitsilos S, Hunt J, Mohler E, Prabhakar A, Poncz M, Dawicki J . Platelet factor 4 localization in carotid atherosclerotic plaques: correlation with clinical parameters. Thromb Haemost. 2003; 90(6):1112-20. DOI: 10.1160/TH03-02-0069. View

10.

Mayadas T, Johnson R, Rayburn H, Hynes R, Wagner D . Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell. 1993; 74(3):541-54. DOI: 10.1016/0092-8674(93)80055-j. View

11.

Waldner M, Wirtz S, Jefremow A, Warntjen M, Neufert C, Atreya R . VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer. J Exp Med. 2010; 207(13):2855-68. PMC: 3005238. DOI: 10.1084/jem.20100438. View

12.

Wassmer S, Combes V, Candal F, Juhan-Vague I, Grau G . Platelets potentiate brain endothelial alterations induced by Plasmodium falciparum. Infect Immun. 2005; 74(1):645-53. PMC: 1346683. DOI: 10.1128/IAI.74.1.645-653.2006. View

13.

Krettek A, Fager G, Rosmond C, Bondjers G, LUSTIG F . Expression of PDGF receptors and ligand-induced migration of partially differentiated human monocyte-derived macrophages. Influence of IFN-gamma and TGF-beta. Atherosclerosis. 2001; 156(2):267-75. DOI: 10.1016/s0021-9150(00)00644-4. View

14.

Boilard E, Nigrovic P, Larabee K, Watts G, Coblyn J, Weinblatt M . Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science. 2010; 327(5965):580-3. PMC: 2927861. DOI: 10.1126/science.1181928. View

15.

Edelstein L, Bray P . MicroRNAs in platelet production and activation. Blood. 2011; 117(20):5289-96. PMC: 3109704. DOI: 10.1182/blood-2011-01-292011. View

16.

Mause S, von Hundelshausen P, Zernecke A, Koenen R, Weber C . Platelet microparticles: a transcellular delivery system for RANTES promoting monocyte recruitment on endothelium. Arterioscler Thromb Vasc Biol. 2005; 25(7):1512-8. DOI: 10.1161/01.ATV.0000170133.43608.37. View

17.

Mustard J, Packham M, Rowsell H, Jorgensen L . The role of platelets in thrombosis and atherosclerosis. Thromb Diath Haemorrh Suppl. 1967; 26:261-74. View

18.

Wachtman L, Tarwater P, Queen S, Adams R, Mankowski J . Platelet decline: an early predictive hematologic marker of simian immunodeficiency virus central nervous system disease. J Neurovirol. 2006; 12(1):25-33. DOI: 10.1080/13550280500516484. View

19.

Koseoglu S, Flaumenhaft R . Advances in platelet granule biology. Curr Opin Hematol. 2013; 20(5):464-71. DOI: 10.1097/MOH.0b013e3283632e6b. View

20.

Wassmer S, de Souza J, Frere C, Candal F, Juhan-Vague I, Grau G . TGF-beta1 released from activated platelets can induce TNF-stimulated human brain endothelium apoptosis: a new mechanism for microvascular lesion during cerebral malaria. J Immunol. 2006; 176(2):1180-4. DOI: 10.4049/jimmunol.176.2.1180. View