MicroRNAs: Genomics, Biogenesis, Mechanism, and Function

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2004 Jan 28

PMID 14744438

Citations 16968

Authors

David P Bartel

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) are endogenous approximately 22 nt RNAs that can play important regulatory roles in animals and plants by targeting mRNAs for cleavage or translational repression. Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.

Citing Articles

Nanotechnology-leveraged CRISPR/Cas systems: icebreaking in trace cancer-related nucleic acids biosensing.

Peng W, Shi M, Hu B, Jia J, Li X, Wang N Mol Cancer. 2025; 24(1):78.

PMID: 40087758 DOI: 10.1186/s12943-024-02222-5.

Molecular mechanisms of miR-192 in cancer: a biomarker and therapeutic target.

Yang Y, Razak S, Ismail I, Ma Y, Yunus M Cancer Cell Int. 2025; 25(1):94.

PMID: 40087755 DOI: 10.1186/s12935-025-03666-5.

Cellular Phenotypic Transformation During Atherosclerosis: The Potential Role of miRNAs as Biomarkers.

Wassaifi S, Kaeffer B, Zarrouk S Int J Mol Sci. 2025; 26(5).

PMID: 40076710 PMC: 11900927. DOI: 10.3390/ijms26052083.

Profiling of miRNAs Contained in Circulating Extracellular Vesicles and Associated with Sepsis Development in Burn Patients: A Proof-of-Concept Study.

Schiavello M, Bosco O, Vizio B, Sciarrillo A, Pensa A, Pivetta E Int J Mol Sci. 2025; 26(5).

PMID: 40076471 PMC: 11899136. DOI: 10.3390/ijms26051844.

Fish MicroRNA Responses to Thermal Stress: Insights and Implications for Aquaculture and Conservation Amid Global Warming.

Lin T, Meegaskumbura M Animals (Basel). 2025; 15(5).

PMID: 40075907 PMC: 11898199. DOI: 10.3390/ani15050624.