Reflux Aspiration in Lungs of Dogs with Respiratory Disease and in Healthy West Highland White Terriers

Overview

Journal J Vet Intern Med

Specialties General Medicine
Veterinary Medicine

Date 2018 Oct 13

PMID 30311983

Citations 14

Authors

O L Merita Maatta

Henna P Laurila

Saila Holopainen

Liisa Lilja-Maula

Marika Melamies

Sanna J Viitanen

L R Johnson

Ninna Koho

Mikko Neuvonen

Mikko Niemi

Minna M Rajamaki

Affiliations

Soon will be listed here.

Abstract

Background: Gastroesophageal reflux and microaspiration (MA) of gastric juice are associated with various human respiratory diseases but not in dogs.

Objective: To detect the presence of bile acids in bronchoalveolar lavage fluid (BALF) of dogs with various respiratory diseases.

Animals: Twenty-seven West Highland White Terriers (WHWTs) with canine idiopathic pulmonary fibrosis (CIPF), 11 dogs with bacterial pneumonia (BP), 13 with chronic bronchitis (CB), 9 with eosinophilic bronchopneumopathy (EBP), 19 with laryngeal dysfunction (LD), 8 Irish Wolfhounds (IWHs) with previous BPs, 13 healthy WHWTs, all privately owned dogs, and 6 healthy research colony Beagles METHODS: Prospective cross-sectional observational study with convenience sampling of dogs. Bile acids were measured by mass spectrometry in BALF samples. Total bile acid (TBA) concentration was calculated as a sum of 17 different bile acids.

Results: Concentrations of TBA were above the limit of quantification in 78% of CIPF, 45% of BP, 62% of CB, 44% of EBP, 68% of LD, and 13% of IWH dogs. In healthy dogs, bile acids were detected less commonly in Beagles (0/6) than in healthy WHWTs (10/13). Concentrations of TBA were significantly higher in CIPF (median 0.013 μM, range not quantifiable [n.q.]-0.14 μM, P < .001), healthy WHWTs (0.0052 μM, n.q.-1.2 μM, P = .003), LD (0.010 μM, n.q.-2.3 μM, P = .015), and CB (0.0078 μM, n.q.-0.073 μM, P = .018) groups compared to Beagles (0 μM, n.q.).

Conclusion And Clinical Importance: These results suggest that MA occurs in various respiratory diseases of dogs and also in healthy WHWTs.

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References

Casanova C, Baudet J, Velasco M, Martin J, Aguirre-Jaime A, de Torres J . Increased gastro-oesophageal reflux disease in patients with severe COPD. Eur Respir J. 2004; 23(6):841-5. DOI: 10.1183/09031936.04.00107004. View

Viitanen S, Laurila H, Lilja-Maula L, Melamies M, Rantala M, Rajamaki M . Serum C-reactive protein as a diagnostic biomarker in dogs with bacterial respiratory diseases. J Vet Intern Med. 2013; 28(1):84-91. PMC: 4895528. DOI: 10.1111/jvim.12262. View

Tart K, Babski D, Lee J . Potential risks, prognostic indicators, and diagnostic and treatment modalities affecting survival in dogs with presumptive aspiration pneumonia: 125 cases (2005-2008). J Vet Emerg Crit Care (San Antonio). 2010; 20(3):319-29. DOI: 10.1111/j.1476-4431.2010.00542.x. View

Lee J, Song J, Wolters P, Elicker B, King Jr T, Kim D . Bronchoalveolar lavage pepsin in acute exacerbation of idiopathic pulmonary fibrosis. Eur Respir J. 2011; 39(2):352-8. PMC: 5529033. DOI: 10.1183/09031936.00050911. View

Parikh S, Brownlee I, Robertson A, Manning N, Johnson G, Brodlie M . Are the enzymatic methods currently being used to measure bronchoalveolar lavage bile salt levels fit for purpose?. J Heart Lung Transplant. 2013; 32(4):418-23. DOI: 10.1016/j.healun.2012.12.008. View

Greenwell C, Brain P . Aspiration pneumonia in the Irish wolfhound: a possible breed predisposition. J Small Anim Pract. 2014; 55(10):515-20. DOI: 10.1111/jsap.12269. View

Shaver S, Barbur L, Jimenez D, Brainard B, Cornell K, Radlinsky M . Evaluation of Gastroesophageal Reflux in Anesthetized Dogs with Brachycephalic Syndrome. J Am Anim Hosp Assoc. 2016; 53(1):24-31. DOI: 10.5326/JAAHA-MS-6281. View

Lin Y, Tsai C, Chien L, Chiou H, Jeng C . Newly diagnosed gastroesophageal reflux disease increased the risk of acute exacerbation of chronic obstructive pulmonary disease during the first year following diagnosis--a nationwide population-based cohort study. Int J Clin Pract. 2014; 69(3):350-7. DOI: 10.1111/ijcp.12501. View

Brodlie M, Aseeri A, Lordan J, Robertson A, McKean M, Corris P . Bile acid aspiration in people with cystic fibrosis before and after lung transplantation. Eur Respir J. 2015; 46(6):1820-3. PMC: 4664606. DOI: 10.1183/13993003.00891-2015. View

10.

Lee J, Collard H, Anstrom K, Martinez F, Noth I, Roberts R . Anti-acid treatment and disease progression in idiopathic pulmonary fibrosis: an analysis of data from three randomised controlled trials. Lancet Respir Med. 2014; 1(5):369-76. PMC: 4059609. DOI: 10.1016/S2213-2600(13)70105-X. View

11.

Raghu G, Morrow E, Collins B, Ho L, Hinojosa M, Hayes J . Laparoscopic anti-reflux surgery for idiopathic pulmonary fibrosis at a single centre. Eur Respir J. 2016; 48(3):826-32. DOI: 10.1183/13993003.00488-2016. View

12.

Johnson L . Laryngeal structure and function in dogs with cough. J Am Vet Med Assoc. 2016; 249(2):195-201. DOI: 10.2460/javma.249.2.195. View

13.

Trinick R, Johnston N, Dalzell A, McNamara P . Reflux aspiration in children with neurodisability--a significant problem, but can we measure it?. J Pediatr Surg. 2012; 47(2):291-8. DOI: 10.1016/j.jpedsurg.2011.11.019. View

14.

Syrja P, Heikkila H, Lilja-Maula L, Krafft E, Clercx C, Day M . The histopathology of idiopathic pulmonary fibrosis in West Highland white terriers shares features of both non-specific interstitial pneumonia and usual interstitial pneumonia in man. J Comp Pathol. 2013; 149(2-3):303-13. DOI: 10.1016/j.jcpa.2013.03.006. View

15.

Linden P, Gilbert R, Yeap B, Boyle K, Deykin A, Jaklitsch M . Laparoscopic fundoplication in patients with end-stage lung disease awaiting transplantation. J Thorac Cardiovasc Surg. 2006; 131(2):438-46. DOI: 10.1016/j.jtcvs.2005.10.014. View

16.

Tarvin K, Twedt D, Monnet E . Prospective Controlled Study of Gastroesophageal Reflux in Dogs with Naturally Occurring Laryngeal Paralysis. Vet Surg. 2016; 45(7):916-921. DOI: 10.1111/vsu.12539. View

17.

Mayhew P, Marks S, Pollard R, Culp W, Kass P . Prospective evaluation of surgical management of sliding hiatal hernia and gastroesophageal reflux in dogs. Vet Surg. 2017; 46(8):1098-1109. DOI: 10.1111/vsu.12684. View

18.

Raghavendran K, Nemzek J, Napolitano L, Knight P . Aspiration-induced lung injury. Crit Care Med. 2011; 39(4):818-26. PMC: 3102154. DOI: 10.1097/CCM.0b013e31820a856b. View

19.

Kogan D, Johnson L, Sturges B, Jandrey K, Pollard R . Etiology and clinical outcome in dogs with aspiration pneumonia: 88 cases (2004-2006). J Am Vet Med Assoc. 2008; 233(11):1748-55. DOI: 10.2460/javma.233.11.1748. View

20.

Aldhahrani A, Verdon B, Ward C, Pearson J . Effects of bile acids on human airway epithelial cells: implications for aerodigestive diseases. ERJ Open Res. 2017; 3(1). PMC: 5360888. DOI: 10.1183/23120541.00107-2016. View