The Therapeutic Potential of Bone Marrow Mesenchymal Stem Cells in Premature Ovarian Failure

Overview

Journal Stem Cell Res Ther

Publisher Biomed Central

Date 2018 Oct 6

PMID 30286808

Citations 61

Authors

Yantao He

Dongmei Chen

Lingling Yang

Qiaoni Hou

Huiming Ma

Xian Xu

Affiliations

Soon will be listed here.

Abstract

With the development of regenerative medicine, a variety of mesenchymal stem cells (MSCs) are increasingly considered for the treatment of premature ovarian failure (POF). Reportedly, bone marrow-derived MSCs (BMSCs) improve the ovarian reserve, which mainly depends on homing and paracrine activities. Furthermore, paracrine factors secreted by these stem cells play an important role in ovarian recovery. Relevant studies indicate that BMSC transplantation has some positive effects on the treatment of POF in animals, but BMSCs are not widely applied in clinical therapy. Clinical trials are ongoing despite the fact that several patients experiencing BMSC transplantation recover their normal menstrual cycles and even give birth to babies. In this review, we discuss the possible therapeutic mechanisms of BMSCs for POF, migration, antiapoptosis, antifibrosis, angiogenesis, anti-inflammation, immunoregulation, and oxidative stress, which provide the theoretical basis for further study and clinical therapy.

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