Silica/Polyethylene Glycol Hybrid Materials Prepared by a Sol-Gel Method and Containing Chlorogenic Acid

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2018 Sep 28

PMID 30257424

Citations 10

Authors

Michelina Catauro

Elisabetta Tranquillo

Alessia Salzillo

Lucia Capasso

Michela Illiano

Luigi Sapio

Silvio Naviglio

Affiliations

Soon will be listed here.

Abstract

Chlorogenic acid (CGA) is a very common dietary polyphenolic compound. CGA is becoming very attractive due to its potential use as preventive and therapeutic agent in many diseases, including cancer. Inorganic/organic hybrid materials are gaining considerable attention in the biomedical field. The sol-gel process provides a useful way to obtain functional organic/inorganic hybrids. The aim of this study was to synthesize silica/polyethylene glycol (PEG) hybrids with different percentages of CGA by sol-gel technique and to investigate their impact on the cancer cell proliferation. Synthesized materials have been chemically characterized through the FTIR spectroscopy and their bioactivity evaluated looking by SEM at their ability to produce a hydroxyapatite layer on their surface upon incubation with simulated body fluid (SBF). Finally, their effects on cell proliferation were studied in cell lines by direct cell number counting, MTT, flow cytometry-based cell-cycle and cell death assays, and immunoblotting experiments. Notably, we found that SiO₂/PEG/CGA hybrids exhibit clear antiproliferative effects in different tumor, including breast cancer and osteosarcoma, cell lines in a CGA dependent manner, but not in normal cells. Overall, our results increase the evidence of CGA as a possible anticancer agent and illustrate the potential for clinical applications of sol-gel synthesized SiO₂/PEG/CGA materials.

Citing Articles

Cationic Gas-Permeable Mold Fabrication Using Sol-Gel Polymerization for Nano-Injection Molding.

Miura S, Yamagishi R, Ando M, Teramae A, Hachikubo Y, Yokoyama Y Gels. 2024; 10(7).

PMID: 39057476 PMC: 11275382. DOI: 10.3390/gels10070453.

Antibacterial and Cytotoxic Silica-Polycaprolactone-Chlorogenic Acid Hybrids by Sol-Gel Route.

Catauro M, DAngelo A, Viola V, Cimmino G, Pacifico S Molecules. 2023; 28(8).

PMID: 37110721 PMC: 10146286. DOI: 10.3390/molecules28083486.

The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review.

Wang L, Pan X, Jiang L, Chu Y, Gao S, Jiang X Front Nutr. 2022; 9:943911.

PMID: 35845802 PMC: 9278960. DOI: 10.3389/fnut.2022.943911.

Innovation through Tradition: The Current Challenges in Cancer Treatment.

Sapio L, Naviglio S Int J Mol Sci. 2022; 23(10).

PMID: 35628105 PMC: 9141447. DOI: 10.3390/ijms23105296.

Synthesis, Structural, Morphological and Thermal Characterization of Five Different Silica-Polyethylene Glycol-Chlorogenic Acid Hybrid Materials.

Catauro M, Siler P, Masilko J, Risoluti R, Vecchio Ciprioti S Polymers (Basel). 2021; 13(10).

PMID: 34069126 PMC: 8156718. DOI: 10.3390/polym13101586.

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