Drug Release of Hybrid Materials Containing Fe(II)Citrate Synthesized by Sol-Gel Technique

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2018 Nov 17

PMID 30441749

Citations 7

Authors

Michelina Catauro

Elisabetta Tranquillo

Federico Barrino

Ignazio Blanco

Francesco Dal Poggetto

Daniele Naviglio

Affiliations

Soon will be listed here.

Abstract

The use of oral iron integration is commonly recommended for the treatment of iron deficiency, nevertheless the diagnosis and treatment of this disease could clearly be improved. The aim of this work was the synthesis of therapeutic systems, iron (II) based, by sol-gel method. In an SiO₂ matrix, we embedded different weight percentages of polyethylene glycol (PEG) and ferrous citrate (Fe(II)C) for drug delivery applications. Fourier Transform Infrared (FTIR) spectroscopy was used to study the interactions among different components in the hybrid materials. Release kinetics in a simulated body fluid (SBF) were investigated and the amount of Fe released was detected by Ultraviolet⁻Visible spectroscopy (UV-VIS) after reaction with ortho-phenantroline. Furthermore, the biological characterization was carried out. The bioactivity of the synthesized hybrid materials was evaluated by the formation of a layer of hydroxyapatite on the surface of samples soaked in SBF using FTIR spectroscopy. Finally, also, the potential antibacterial properties of the different materials against two different bacteria, and , were investigated.

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