The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2022 Jul 18

PMID 35845802

Authors

Liang Wang

Xiaoqi Pan

Lishi Jiang

Yu Chu

Song Gao

Xingyue Jiang

Yuhui Zhang

Yan Chen

Shajie Luo

Cheng Peng

Affiliations

Soon will be listed here.

Abstract

Chlorogenic acid (CGA), also known as coffee tannic acid and 3-caffeoylquinic acid, is a water-soluble polyphenolic phenylacrylate compound produced by plants through the shikimic acid pathway during aerobic respiration. CGA is widely found in higher dicotyledonous plants, ferns, and many Chinese medicine plants, which enjoy the reputation of "plant gold." We have summarized the biological activities of CGA, which are mainly shown as anti-oxidant, liver and kidney protection, anti-bacterial, anti-tumor, regulation of glucose metabolism and lipid metabolism, anti-inflammatory, protection of the nervous system, and action on blood vessels. We further determined the main applications of CGA in the food industry, including food additives, food storage, food composition modification, food packaging materials, functional food materials, and prebiotics. With a view to the theoretical improvement of CGA, biological activity mechanism, and subsequent development and utilization provide reference and scientific basis.

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References

Yun Y, Koo J, Kim S, Kong W . Cloning and Expression Analysis of Phenylalanine Ammonia-Lyase Gene in the Mycelium and Fruit Body of the Edible Mushroom Flammulina velutipes. Mycobiology. 2015; 43(3):327-32. PMC: 4630440. DOI: 10.5941/MYCO.2015.43.3.327. View

Lupi L, Cucielo M, Silveira H, Gaiotte L, Cesario R, Seiva F . The role of Toll-like receptor 4 signaling pathway in ovarian, cervical, and endometrial cancers. Life Sci. 2020; 247:117435. DOI: 10.1016/j.lfs.2020.117435. View

Lee T, Kang I, Kim B, Sim H, Kim D, Ahn J . Experimental Pretreatment with Chlorogenic Acid Prevents Transient Ischemia-Induced Cognitive Decline and Neuronal Damage in the Hippocampus through Anti-Oxidative and Anti-Inflammatory Effects. Molecules. 2020; 25(16). PMC: 7463954. DOI: 10.3390/molecules25163578. View

Jeon J, Kim H, Jeong I, Hong S, Oh M, Park K . Determination of chlorogenic acids and caffeine in homemade brewed coffee prepared under various conditions. J Chromatogr B Analyt Technol Biomed Life Sci. 2017; 1064:115-123. DOI: 10.1016/j.jchromb.2017.08.041. View

Lee Y, Shin D, Lim B . Chlorogenic Acid Improves Symptoms of Inflammatory Bowel Disease in Interleukin-10 Knockout Mice. J Med Food. 2020; 23(10):1043-1053. DOI: 10.1089/jmf.2019.4621. View

Chen Y, Geng S, Liu B . Three common caffeoylquinic acids as potential hypoglycemic nutraceuticals: Evaluation of α-glucosidase inhibitory activity and glucose consumption in HepG2 cells. J Food Biochem. 2020; 44(9):e13361. DOI: 10.1111/jfbc.13361. View

Lu Y, Li S, Xu H, Zhang T, Lin X, Wu X . Effect of Covalent Interaction with Chlorogenic Acid on the Allergenic Capacity of Ovalbumin. J Agric Food Chem. 2018; 66(37):9794-9800. DOI: 10.1021/acs.jafc.8b03410. View

Cheng X, Li K, Xu S, Li P, Yan Y, Wang G . Applying chlorogenic acid in an alginate scaffold of chondrocytes can improve the repair of damaged articular cartilage. PLoS One. 2018; 13(4):e0195326. PMC: 5886530. DOI: 10.1371/journal.pone.0195326. View

Zou Y, Zhang C, Wang P, Zhang Y, Zhang H . Electrospun chitosan/polycaprolactone nanofibers containing chlorogenic acid-loaded halloysite nanotube for active food packaging. Carbohydr Polym. 2020; 247:116711. DOI: 10.1016/j.carbpol.2020.116711. View

10.

Oh N, Lee J, Joung J, Kim K, Shin Y, Lee K . Microbiological characterization and functionality of set-type yogurt fermented with potential prebiotic substrates Cudrania tricuspidata and Morus alba L. leaf extracts. J Dairy Sci. 2016; 99(8):6014-6025. DOI: 10.3168/jds.2015-10814. View

11.

Sadeghi Ekbatan S, Li X, Ghorbani M, Azadi B, Kubow S . Chlorogenic Acid and Its Microbial Metabolites Exert Anti-Proliferative Effects, S-Phase Cell-Cycle Arrest and Apoptosis in Human Colon Cancer Caco-2 Cells. Int J Mol Sci. 2018; 19(3). PMC: 5877584. DOI: 10.3390/ijms19030723. View

12.

Craig A, Fields C, Liang N, Kitts D, Erickson A . Performance review of a fast HPLC-UV method for the quantification of chlorogenic acids in green coffee bean extracts. Talanta. 2016; 154:481-5. DOI: 10.1016/j.talanta.2016.03.101. View

13.

Clifford M, Kerimi A, Williamson G . Bioavailability and metabolism of chlorogenic acids (acyl-quinic acids) in humans. Compr Rev Food Sci Food Saf. 2020; 19(4):1299-1352. DOI: 10.1111/1541-4337.12518. View

14.

Ngo Lemba Tom E, Girard-Thernier C, Demougeot C . The Janus face of chlorogenic acid on vascular reactivity: A study on rat isolated vessels. Phytomedicine. 2016; 23(10):1037-42. DOI: 10.1016/j.phymed.2016.06.012. View

15.

Qiu X, Jacobsen C, Sorensen A . The effect of rosemary (Rosmarinus officinalis L.) extract on the oxidative stability of lipids in cow and soy milk enriched with fish oil. Food Chem. 2018; 263:119-126. DOI: 10.1016/j.foodchem.2018.04.106. View

16.

Chen X, Cai W, Xia J, Yu H, Wang Q, Pang F . Metabolomic and Transcriptomic Analyses Reveal that Blue Light Promotes Chlorogenic Acid Synthesis in Strawberry. J Agric Food Chem. 2020; 68(44):12485-12492. DOI: 10.1021/acs.jafc.0c05020. View

17.

Chen F, Zhang H, Zhao N, Yang X, Du E, Huang S . Effect of chlorogenic acid on intestinal inflammation, antioxidant status, and microbial community of young hens challenged with acute heat stress. Anim Sci J. 2021; 92(1):e13619. DOI: 10.1111/asj.13619. View

18.

Refolo M, Lippolis C, Carella N, Cavallini A, Messa C, DAlessandro R . Chlorogenic Acid Improves the Regorafenib Effects in Human Hepatocellular Carcinoma Cells. Int J Mol Sci. 2018; 19(5). PMC: 5983789. DOI: 10.3390/ijms19051518. View

19.

Chen P, Shih T, Chang K, Wang J, Yang C, Chang Y . Potential of galled leaves of Goji () as functional food. BMC Nutr. 2020; 6:26. PMC: 7339520. DOI: 10.1186/s40795-020-00351-w. View

20.

Gong X, Su X, Zhan K, Zhao G . The protective effect of chlorogenic acid on bovine mammary epithelial cells and neutrophil function. J Dairy Sci. 2018; 101(11):10089-10097. DOI: 10.3168/jds.2017-14328. View