Polyphenol Nanoformulations for Cancer Therapy: Experimental Evidence and Clinical Perspective

Overview

Journal Int J Nanomedicine

Publisher Dove Medical Press

Specialty Biotechnology

Date 2017 Apr 25

PMID 28435252

Citations 89

Authors

Yasamin Davatgaran-Taghipour

Salar Masoomzadeh

Mohammad Hosein Farzaei

Roodabeh Bahramsoltani

Zahra Karimi-Soureh

Roja Rahimi

Mohammad Abdollahi

Affiliations

Soon will be listed here.

Abstract

Cancer is defined as the abnormal cell growth that can cause life-threatening malignancies with high financial costs for patients as well as the health care system. Natural polyphenols have long been used for the prevention and treatment of several disorders due to their antioxidant, anti-inflammatory, cytotoxic, antineoplastic, and immunomodulatory effects discussed in the literature; thus, these phytochemicals are potentially able to act as chemopreventive and chemotherapeutic agents in different types of cancer. One of the problems regarding the use of polyphenolic compounds is their low bioavailability. Different types of formulations have been designed for the improvement of bioavailability of these compounds, nanonization being one of the most notable approaches among them. This study aimed to review current data on the nanoformulations of natural polyphenols as chemopreventive and chemotherapeutic agents and to discuss their molecular anticancer mechanisms of action. Nanoformulations of natural polyphenols as bioactive agents, including resveratrol, curcumin, quercetin, epigallocatechin-3-gallate, chrysin, baicalein, luteolin, honokiol, silibinin, and coumarin derivatives, in a dose-dependent manner, result in better efficacy for the prevention and treatment of cancer. The impact of nanoformulation methods for these natural agents on tumor cells has gained wider attention due to improvement in targeted therapy and bioavailability, as well as enhancement of stability. Today, several nanoformulations are designed for delivery of polyphenolic compounds, including nanosuspensions, solid lipid nanoparticles, liposomes, gold nanoparticles, and polymeric nanoparticles, which have resulted in better antineoplastic activity, higher intracellular concentration of polyphenols, slow and sustained release of the drugs, and improvement of proapoptotic activity against tumor cells. To conclude, natural polyphenols demonstrate remarkable anticancer potential in pharmacotherapy; however, the obstacles in terms of their bioavailability in and toxicity to normal cells, as well as targeted drug delivery to malignant cells, can be overcome using nanoformulation-based technologies, which optimize the bioefficacy of these natural drugs.

Citing Articles

Research Progress of in the Treatment of Gastrointestinal Cancer.

Wang L, Ni B, Wang J, Zhou J, Wang J, Jiang J Integr Cancer Ther. 2024; 23:15347354241302049.

PMID: 39610320 PMC: 11605761. DOI: 10.1177/15347354241302049.

Silibinin-Loaded Amphiphilic PLGA-Poloxamer Nanoparticles: Physicochemical Characterization, Release Kinetics, and Bioactivity Evaluation in Lung Cancer Cells.

Villapiano F, Piccioni M, DAria F, Crispi S, Rassu G, Giunchedi P Materials (Basel). 2024; 17(22).

PMID: 39597304 PMC: 11595691. DOI: 10.3390/ma17225480.

Non-targeted metabolomics and pseudo-targeted lipidomics combined with gut microbes reveal the protective effects of (Thunb.) Raf. in ulcerative colitis mice.

Huang H, Jiang J, Fan Y, Ding X, Li F, Liu C Front Cell Infect Microbiol. 2024; 14:1397735.

PMID: 39473926 PMC: 11518848. DOI: 10.3389/fcimb.2024.1397735.

Unlocking the potential of flavonoid-infused drug delivery systems for diabetic wound healing with a mechanistic exploration.

Chowdhury A, Mazumder P Inflammopharmacology. 2024; 32(5):2861-2896.

PMID: 39217278 DOI: 10.1007/s10787-024-01561-5.

Polyphenols Modulate the miRNAs Expression that Involved in Glioblastoma.

Rezaie M, Nasehi M, Shimia M, Ebrahimnezhad M, Yousefi B, Majidinia M Mini Rev Med Chem. 2024; 24(21):1953-1969.

PMID: 38639278 DOI: 10.2174/0113895575304605240408105201.

References

Ochwangi D, Kimwele C, Oduma J, Gathumbi P, Mbaria J, Kiama S . Medicinal plants used in treatment and management of cancer in Kakamega County, Kenya. J Ethnopharmacol. 2013; 151(3):1040-1055. DOI: 10.1016/j.jep.2013.11.051. View

Wang X, Wang Y, Chen Z, Shin D . Advances of cancer therapy by nanotechnology. Cancer Res Treat. 2009; 41(1):1-11. PMC: 2699095. DOI: 10.4143/crt.2009.41.1.1. View

Le Marchand L . Cancer preventive effects of flavonoids--a review. Biomed Pharmacother. 2002; 56(6):296-301. DOI: 10.1016/s0753-3322(02)00186-5. View

Mehnert W, Mader K . Solid lipid nanoparticles: production, characterization and applications. Adv Drug Deliv Rev. 2001; 47(2-3):165-96. DOI: 10.1016/s0169-409x(01)00105-3. View

Toure A, Xueming X . Flaxseed Lignans: Source, Biosynthesis, Metabolism, Antioxidant Activity, Bio-Active Components, and Health Benefits. Compr Rev Food Sci Food Saf. 2021; 9(3):261-269. DOI: 10.1111/j.1541-4337.2009.00105.x. View

Parhiz H, Roohbakhsh A, Soltani F, Rezaee R, Iranshahi M . Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models. Phytother Res. 2014; 29(3):323-31. DOI: 10.1002/ptr.5256. View

Kumari A, Yadav S, Yadav S . Biodegradable polymeric nanoparticles based drug delivery systems. Colloids Surf B Biointerfaces. 2009; 75(1):1-18. DOI: 10.1016/j.colsurfb.2009.09.001. View

Koopaei N, Abdollahi M . Opportunities and obstacles to the development of nanopharmaceuticals for human use. Daru. 2016; 24(1):23. PMC: 5052974. DOI: 10.1186/s40199-016-0163-8. View

Shin Y, Kang S, Park J, Kim Y, Kim Y, Baek S . Anti-cancer effect of (-)-epigallocatechin-3-gallate (EGCG) in head and neck cancer through repression of transactivation and enhanced degradation of β-catenin. Phytomedicine. 2016; 23(12):1344-1355. DOI: 10.1016/j.phymed.2016.07.005. View

10.

Punfa W, Yodkeeree S, Pitchakarn P, Ampasavate C, Limtrakul P . Enhancement of cellular uptake and cytotoxicity of curcumin-loaded PLGA nanoparticles by conjugation with anti-P-glycoprotein in drug resistance cancer cells. Acta Pharmacol Sin. 2012; 33(6):823-31. PMC: 4010380. DOI: 10.1038/aps.2012.34. View

11.

Brandl M . Liposomes as drug carriers: a technological approach. Biotechnol Annu Rev. 2001; 7:59-85. DOI: 10.1016/s1387-2656(01)07033-8. View

12.

Farzaei M, Bahramsoltani R, Rahimi R . Phytochemicals as Adjunctive with Conventional Anticancer Therapies. Curr Pharm Des. 2016; 22(27):4201-18. DOI: 10.2174/1381612822666160601100823. View

13.

Duraipandy N, Lakra R, Kunnavakkam Vinjimur S, Samanta D, K P, Kiran M . Caging of plumbagin on silver nanoparticles imparts selectivity and sensitivity to plumbagin for targeted cancer cell apoptosis. Metallomics. 2014; 6(11):2025-33. DOI: 10.1039/c4mt00165f. View

14.

Rezaei-Sadabady R, Eidi A, Zarghami N, Barzegar A . Intracellular ROS protection efficiency and free radical-scavenging activity of quercetin and quercetin-encapsulated liposomes. Artif Cells Nanomed Biotechnol. 2014; 44(1):128-34. DOI: 10.3109/21691401.2014.926456. View

15.

Rejinold N, Sreerekha P, Chennazhi K, Nair S, Jayakumar R . Biocompatible, biodegradable and thermo-sensitive chitosan-g-poly (N-isopropylacrylamide) nanocarrier for curcumin drug delivery. Int J Biol Macromol. 2011; 49(2):161-72. DOI: 10.1016/j.ijbiomac.2011.04.008. View

16.

Bhattacharyya S, Paul S, De A, Das D, Samadder A, Boujedaini N . Poly (lactide-co-glycolide) acid nanoencapsulation of a synthetic coumarin: cytotoxicity and bio-distribution in mice, in cancer cell line and interaction with calf thymus DNA as target. Toxicol Appl Pharmacol. 2011; 253(3):270-81. DOI: 10.1016/j.taap.2011.04.010. View

17.

Raveendran R, Bhuvaneshwar G, Sharma C . Hemocompatible curcumin-dextran micelles as pH sensitive pro-drugs for enhanced therapeutic efficacy in cancer cells. Carbohydr Polym. 2015; 137:497-507. DOI: 10.1016/j.carbpol.2015.11.017. View

18.

Sabzichi M, Hamishehkar H, Ramezani F, Sharifi S, Tabasinezhad M, Pirouzpanah M . Luteolin-loaded phytosomes sensitize human breast carcinoma MDA-MB 231 cells to doxorubicin by suppressing Nrf2 mediated signalling. Asian Pac J Cancer Prev. 2014; 15(13):5311-6. DOI: 10.7314/apjcp.2014.15.13.5311. View

19.

Zhang B, Pan X, Cobb G, Anderson T . microRNAs as oncogenes and tumor suppressors. Dev Biol. 2006; 302(1):1-12. DOI: 10.1016/j.ydbio.2006.08.028. View

20.

Phan Q, Le M, Thu Huong Le T, Tran T, Xuan P, Thu Ha P . Characteristics and cytotoxicity of folate-modified curcumin-loaded PLA-PEG micellar nano systems with various PLA:PEG ratios. Int J Pharm. 2016; 507(1-2):32-40. DOI: 10.1016/j.ijpharm.2016.05.003. View