The Relationship Between Bruch's Membrane Opening-Minimum Rim Width and Retinal Nerve Fiber Layer Thickness and a New Index Using a Neural Network

Overview

Journal Transl Vis Sci Technol

Specialties Biomedical Engineering
Ophthalmology

Date 2018 Aug 31

PMID 30159207

Citations 13

Authors

Keunheung Park

Jinmi Kim

Jiwoong Lee

Affiliations

Soon will be listed here.

Abstract

Purpose: We evaluate the relationship between Bruch's membrane opening minimum rim width (BMO-MRW) and peripapillary retinal nerve fiber layer thickness (pRNFLT) and develop a new parameter combining BMO-MRW and pRNFLT using a neural network to maximize their compensatory values.

Methods: A total of 402 subjects were divided into two groups: 273 (validation group) and 129 (neural net training) subjects. Linear quadratic and broken-stick regression models were used to explore the relationship between BMO-MRW and pRNFLT. A multilayer neural network was used to create a combined parameter, and diagnostic performances were compared using area under the receiver operating characteristic curves (AUROCs).

Results: Regression analyses between BMO-MRW and pRNFLT revealed that the broken-stick model afforded the best fit. Globally, the tipping point was a BMO-MRW of 226.5 μm. BMO-MRW and pRNFLT were correlated significantly with visual field. When differentiating normal from glaucoma subjects, the neural network exhibited the largest AUROC. When differentiating normal from early glaucoma subjects, the overall diagnostic performance decreased, but the neural network still exhibited the largest AUROC.

Conclusions: The optimal relationship between BMO-MRW and pRNFLT was revealed using the broken-stick model. Considerable BMO-MRW thinning preceded pRNFLT thinning. The neural network significantly improved diagnostic power by combining BMO-MRW and pRNFLT.

Translational Relevance: A combined index featuring BMO-MRW and pRNFLT data can aid clinical decision-making, particularly when individual parameters yield confusing results. Our neural network effectively combines information from separate parameters.

Citing Articles

Sources of Discrepancy between Retinal Nerve Fiber Layer and Bruch's Membrane Opening-Minimum Rim Width Thickness in Eyes with Glaucoma.

Zhuang I, Ashrafkhorasani M, Mohammadzadeh V, Nouri-Mahdavi K Ophthalmol Sci. 2024; 5(1):100601.

PMID: 39411541 PMC: 11474368. DOI: 10.1016/j.xops.2024.100601.

LIMBARE: An Advanced Linear Mixed-Effects Breakpoint Analysis With Robust Estimation Method With Applications to Longitudinal Ophthalmic Studies.

Lee T, Schuman J, Ramos Cadena M, Zhang Y, Wollstein G, Hu J Transl Vis Sci Technol. 2024; 13(1):19.

PMID: 38241038 PMC: 10807490. DOI: 10.1167/tvst.13.1.19.

Identification of Glaucoma in Diabetics Using the Laguna-ONhE Colourimetric Method and OCT Spectralis.

Gonzalez-Hernandez M, Betancor-Caro N, Mesa-Lugo F, Rodriguez-Talavera I, Pareja-Rios A, Guedes-Guedes I J Clin Med. 2023; 12(18).

PMID: 37762816 PMC: 10531930. DOI: 10.3390/jcm12185876.

Effect of Conventional Cataract Surgery and Femtosecond Laser-Assisted Cataract Surgery on Bruch's Membrane Opening-Minimum Rim Width, Retinal Nerve Fiber Layer, and Macular Thickness.

Renones J, Anton A, Gonzalez-Martin J, Carreras H, Loro-Ferrer J J Ophthalmol. 2023; 2023:8345333.

PMID: 36798723 PMC: 9928504. DOI: 10.1155/2023/8345333.

Comparison of retinal nerve fiber layer thickness and Bruch's membrane opening minimum rim width thinning rate in open-angle glaucoma.

Park D, Park S, Na K Sci Rep. 2022; 12(1):16069.

PMID: 36167787 PMC: 9515070. DOI: 10.1038/s41598-022-20423-0.

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