Immunological Studies of Aging. III. Cytokinetic Basis for the Impaired Response of Lymphocytes from Aged Humans to Plant Lectins

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1977 May 1

PMID 300780

Citations 26

Authors

B Inkeles

J B Innes

M M Kuntz

A S Kadish

M E Weksler

Affiliations

Soon will be listed here.

Abstract

The basis for the age-associated defect in the response of lymphocytes to plant lectins has been studied. Using three independent assays we have shown that the number of mitogen-responsive cells is markedly reduced in lymphocyte preparations from old persons. In addition, studies using colchicine bloock and thymidine pulse techniques have revealed a failure of mitogen-responsive cells from old persons to expand into a proliferating pool of lymphocytes as is observed when lymphocytes from young persons are cultured with phytohemagglutinin. Thus, the impaired response of lymphocytes from old persons to mitogens is attributable to a reduced number of mitogen responsive cells and their failure to undergo clonal expansion.

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