Identification of Prognostic Aging-related Genes Associated with Immunosuppression and Inflammation in Head and Neck Squamous Cell Carcinoma

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2020 Nov 24

PMID 33232279

Citations 22

Authors

Jing Yang

Qingshan Jiang

Lijun Liu

Hong Peng

Yaya Wang

Shuyan Li

Yanhua Tang

Jing Yu

Runliang Gan

Zhifeng Liu

Affiliations

Soon will be listed here.

Abstract

Aging is regarded as a dominant risk factor for cancer. Additionally, inflammation and asthenic immune surveillance with aging may facilitate tumor formation and development. However, few studies have comprehensively analyzed the relationship between aging-related genes (AGs) and the prognosis, inflammation and tumor immunity of head and neck squamous cell carcinoma (HNSCC). Here, we initially screened 41 differentially expressed AGs from The Cancer Genome Atlas (TCGA) database. In the training set, a prognosis risk model with seven AGs (APP, CDKN2A, EGFR, HSPD1, IL2RG, PLAU and VEGFA) was constructed and validated in the TCGA test set and the GEO set ( < 0.05). Using univariate and multivariate Cox regression analyses, we confirmed that risk score was an independent prognostic factor of HNSCC patients. In addition, a high risk score was significantly correlated with immunosuppression, and high expression of PLAU, APP and EGFR was the main factor. Furthermore, we confirmed that a high risk score was significantly associated with levels of proinflammatory factors (IL-1α, IL-1β, IL-6 and IL-8) in HNSCC samples. Thus, this risk model may serve as a prognostic signature and provide clues for individualized immunotherapy for HNSCC patients.

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