Cytokine Production Pathway in the Elderly

Overview

Journal Immunol Res

Specialty Allergy & Immunology

Date 1996 Jan 1

PMID 8739567

Citations 25

Authors

C Caruso

G Candore

D Cigna

G Dilorenzo

G Sireci

F Dieli

A Salerno

Affiliations

Soon will be listed here.

Abstract

It is well known that aging is associated with various alterations in lymphoid cell functions, particularly with a progressive decline in immune responsiveness to exogenous antigens and increasing incidence of autoimmune phenomena. Many studies have been focused on the mechanisms of the immunologic features of aging. this review describes our results of studies performed to determine the influence of age on the capacity to produce interleukin-2 (IL-2), interferon-gamma (IFN-gamma), interleukin-4 (IL-4), interleukin-t (IL-5), interleukin-6 (IL-6) and tumor necrosis factor (TNF). Mitogen-stimulated cultures of mononuclear cells (MNC) from human beings were assessed for cytokine-producing capacity. A significant decrease in IFN-gamma and IL-2 production by MNC cultures from elderly individuals was observed. No significant difference was instead observed between cultures from elderly individuals and those from young ones as regards TNF-alpha, IL-4 and IL-6 production. Mitogen or antigen-stimulated cultures of MNC from aged mice also displayed a significant decrease in IFN-gamma and IL-2 production as well as TNF-beta. Instead IL-4 and IL-5 production significantly increased in these cultures. We suggest that this imbalanced cytokine production may well account for the pattern of immune response which may be observed in the elderly, i.e. a normal or increased humoral response (including autoimmune responses) in face of a low T cell immune responsiveness.

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References

Mosmann T, Coffman R . Heterogeneity of cytokine secretion patterns and functions of helper T cells. Adv Immunol. 1989; 46:111-47. DOI: 10.1016/s0065-2776(08)60652-5. View

Dieli F, Sireci G, Lio D, Bonanno C, Salerno A . Major histocompatibility complex regulation of interleukin-5 production in the mouse. Eur J Immunol. 1993; 23(11):2897-902. DOI: 10.1002/eji.1830231125. View

Nagel J, Chopra R, Powers D, Adler W . Effect of age on the human high affinity interleukin 2 receptor of phytohaemagglutinin stimulated peripheral blood lymphocytes. Clin Exp Immunol. 1989; 75(2):286-91. PMC: 1542135. View

Lerner A, Yamada T, Miller R . Pgp-1hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A. Eur J Immunol. 1989; 19(6):977-82. DOI: 10.1002/eji.1830190604. View

Doria G, Frasca D . Ageing and genetic control of immune responsiveness. Immunol Lett. 1994; 40(3):231-3. DOI: 10.1016/0165-2478(94)00061-1. View

Nagelkerken L, Dobber R, Drager A . Age-related changes in lymphokine production related to a decreased number of CD45RBhi CD4+ T cells. Eur J Immunol. 1991; 21(2):273-81. DOI: 10.1002/eji.1830210206. View

Gillis S, Kozak R, Durante M, Weksler M . Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans. J Clin Invest. 1981; 67(4):937-42. PMC: 370650. DOI: 10.1172/jci110143. View

Song L, Kim Y, Chopra R, Proust J, Nagel J, Nordin A . Age-related effects in T cell activation and proliferation. Exp Gerontol. 1993; 28(4-5):313-21. DOI: 10.1016/0531-5565(93)90058-l. View

Ernst D, Weigle W, Hobbs M . Aging and lymphokine production by T cell subsets. Stem Cells. 1993; 11(6):487-98. DOI: 10.1002/stem.5530110618. View

10.

Nagel J, Chopra R, Chrest F, McCoy M, Schneider E, Holbrook N . Decreased proliferation, interleukin 2 synthesis, and interleukin 2 receptor expression are accompanied by decreased mRNA expression in phytohemagglutinin-stimulated cells from elderly donors. J Clin Invest. 1988; 81(4):1096-102. PMC: 329636. DOI: 10.1172/JCI113422. View

11.

Miller R . Age-associated decline in precursor frequency for different T cell-mediated reactions, with preservation of helper or cytotoxic effect per precursor cell. J Immunol. 1984; 132(1):63-8. View

12.

Colucci A, Di Lorenzo G, Ingrassia A, Crescimanno G, Modica M, Candore G . Blood antiphospholipid antibody levels are influenced by age, sex and HLA-B8,DR3 phenotype. Exp Clin Immunogenet. 1992; 9(2):72-9. View

13.

Giordano C, Panto F, Caruso C, Modica M, Zambito A, Sapienza N . Interleukin 2 and soluble interleukin 2-receptor secretion defect in vitro in newly diagnosed type I diabetic patients. Diabetes. 1989; 38(3):310-5. DOI: 10.2337/diab.38.3.310. View

14.

Beutler B, Cerami A . The biology of cachectin/TNF--a primary mediator of the host response. Annu Rev Immunol. 1989; 7:625-55. DOI: 10.1146/annurev.iy.07.040189.003205. View

15.

Lio D, DAnna C, Gervasi F, Cigna D, Modica M, Candore G . In vitro impairment of interleukin-5 production in HLA-B8, DR3-positive individuals implications for immunoglobulin A synthesis dysfunction. Hum Immunol. 1995; 44(3):170-4. DOI: 10.1016/0198-8859(95)00084-4. View

16.

Modica M, Di Lorenzo G, Galluzzo A, Giordano C, Portelli M, Candore G . Soluble interleukin-2 receptor secretion defect in vitro in HLA-B8, DR3 positive subjects. Autoimmunity. 1990; 7(2-3):87-96. DOI: 10.3109/08916939008993381. View

17.

Candore G, Cigna D, Todaro M, De Maria R, Stassi G, Giordano C . T-cell activation in HLA-B8, DR3-positive individuals. Early antigen expression defect in vitro. Hum Immunol. 1995; 42(4):289-94. DOI: 10.1016/0198-8859(94)00103-w. View

18.

Fagiolo U, Cossarizza A, Santacaterina S, Ortolani C, Monti D, Paganelli R . Increased cytokine production by peripheral blood mononuclear cells from healthy elderly people. Ann N Y Acad Sci. 1992; 663:490-3. DOI: 10.1111/j.1749-6632.1992.tb38712.x. View

19.

Romagnani S . Induction of TH1 and TH2 responses: a key role for the 'natural' immune response?. Immunol Today. 1992; 13(10):379-81. DOI: 10.1016/0167-5699(92)90083-J. View

20.

Thoman M, Weigle W . The cellular and subcellular bases of immunosenescence. Adv Immunol. 1989; 46:221-61. DOI: 10.1016/s0065-2776(08)60655-0. View