Tie-Break: Host and Retrotransposons Play TRNA

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 2018 Jun 24

PMID 29934075

Citations 22

Authors

Andrea J Schorn

Rob Martienssen

Affiliations

Soon will be listed here.

Abstract

tRNA fragments (tRFs) are a class of small, regulatory RNAs with diverse functions. 3'-Derived tRFs perfectly match long terminal repeat (LTR)-retroelements which use the 3'-end of tRNAs to prime reverse transcription. Recent work has shown that tRFs target LTR-retroviruses and -transposons for the RNA interference (RNAi) pathway and also inhibit mobility by blocking reverse transcription. The highly conserved tRNA primer binding site (PBS) in LTR-retroelements is a unique target for 3'-tRFs to recognize and block abundant but diverse LTR-retrotransposons that become transcriptionally active during epigenetic reprogramming in development and disease. 3'-tRFs are processed from full-length tRNAs under so far unknown conditions and potentially protect many cell types. tRFs appear to be an ancient link between RNAi, transposons, and genome stability.

Citing Articles

tRNA and tsRNA: From Heterogeneity to Multifaceted Regulators.

Li Y, Yu Z, Jiang W, Lyu X, Guo A, Sun X Biomolecules. 2024; 14(10).

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Pseudouridine guides germline small RNA transport and epigenetic inheritance.

Herridge R, Dolata J, Migliori V, de Santis Alves C, Borges F, Schorn A Nat Struct Mol Biol. 2024; 32(2):277-286.

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The Molecular Impacts of Retrotransposons in Development and Diseases.

Tam P, Leung D Int J Mol Sci. 2023; 24(22).

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The life and times of a tRNA.

Phizicky E, Hopper A RNA. 2023; 29(7):898-957.

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Transposon control as a checkpoint for tissue regeneration.

Angileri K, Bagia N, Feschotte C Development. 2022; 149(22).

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