Heteronanoparticles by Self-Assembly of Ecdysteroid and Doxorubicin Conjugates To Overcome Cancer Resistance

Overview

Journal ACS Med Chem Lett

Publisher American Chemical Society

Specialty Chemistry

Date 2018 May 26

PMID 29795761

Citations 10

Authors

Gaia Fumagalli

Giulia Giorgi

Mate Vagvolgyi

Eleonora Colombo

Michael S Christodoulou

Veronica Collico

Davide Prosperi

Franco Dosio

Attila Hunyadi

Monica Montopoli

Mariafrancesca Hyeraci

Alessandra Silvani

Giordano Lesma

Lisa Dalla Via

Daniele Passarella

Affiliations

Soon will be listed here.

Abstract

Heteronanoparticles (H-NPs) consisting of conjugates characterized by a squalene tail linked to doxorubicin and ecdysteroid derivatives are presented. Biological evaluation on A2780ADR cell line confirms not only the maintenance of the activity of the parental drug but also the ability to overcome cancer resistance. The cell uptake was demonstrated, and the involvement of an endosomal-mediated pathway was suggested.

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