Nitric Oxide-Releasing Macromolecular Scaffolds for Antibacterial Applications

Overview

Journal Adv Healthc Mater

Specialties Biomedical Engineering
Biotechnology

Date 2018 May 15

PMID 29756275

Citations 49

Authors

Lei Yang

Evan S Feura

Mona Jasmine R Ahonen

Mark H Schoenfisch

Affiliations

Soon will be listed here.

Abstract

Exogenous nitric oxide (NO) represents an attractive antibacterial agent because of its ability to both disperse and directly kill bacterial biofilms while avoiding resistance. Due to the challenges associated with administering gaseous NO, NO-releasing macromolecular scaffolds are developed to facilitate NO delivery. This progress report describes the rational design and application of NO-releasing macromolecular scaffolds as antibacterial therapeutics. Special consideration is given to the role of the physicochemical properties of the NO storage vehicles on antibacterial or anti-biofilm activity.

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