What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 2010 Apr 23

PMID 20410298

Citations 103

Authors

Bradford G Hill

Brian P Dranka

Shannon M Bailey

Jack R Lancaster Jr

Victor M Darley-Usmar

Affiliations

Soon will be listed here.

Abstract

Nitric oxide (NO) regulates biological processes through signaling mechanisms that exploit its unique biochemical properties as a free radical. For the last several decades, the key aspects of the chemical properties of NO relevant to biological systems have been defined, but it has been a challenge to assign these to specific cellular processes. Nevertheless, it is now clear that the high affinity of NO for transition metal centers, particularly iron, and the rapid reaction of NO with oxygen-derived free radicals can explain many of its biological and pathological properties. Emerging studies also highlight a growing importance of the secondary metabolites of NO-dependent reactions in the post-translational modification of key metabolic and signaling proteins. In this minireview, we emphasize the current understanding of the biochemistry of NO and place it in a biological context.

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