A Computational Model of Shared Fine-scale Structure in the Human Connectome

Overview

Journal PLoS Comput Biol

Specialty Biology

Date 2018 Apr 18

PMID 29664910

Citations 45

Authors

J Swaroop Guntupalli

Ma Feilong

James V Haxby

Affiliations

Soon will be listed here.

Abstract

Variation in cortical connectivity profiles is typically modeled as having a coarse spatial scale parcellated into interconnected brain areas. We created a high-dimensional common model of the human connectome to search for fine-scale structure that is shared across brains. Projecting individual connectivity data into this new common model connectome accounts for substantially more variance in the human connectome than do previous models. This newly discovered shared structure is closely related to fine-scale distinctions in representations of information. These results reveal a shared fine-scale structure that is a major component of the human connectome that coexists with coarse-scale, areal structure. This shared fine-scale structure was not captured in previous models and was, therefore, inaccessible to analysis and study.

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