A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

Overview

Journal Cancer Cell

Publisher Cell Press

Specialty Oncology

Date 2018 Apr 7

PMID 29622464

Citations 318

Authors

Ashton C Berger

Anil Korkut

Rupa S Kanchi

Apurva M Hegde

Walter Lenoir

Wenbin Liu

Yuexin Liu

Huihui Fan

Hui Shen

Visweswaran Ravikumar

Arvind Rao

Andre Schultz

Xubin Li

Pavel Sumazin

Cecilia Williams

Pieter Mestdagh

Preethi H Gunaratne

Christina Yau

Reanne Bowlby

A Gordon Robertson

Daniel G Tiezzi

Chen Wang

Andrew D Cherniack

Andrew K Godwin

Nicole M Kuderer

Janet S Rader

Rosemary E Zuna

Anil K Sood

Alexander J Lazar

Akinyemi I Ojesina

Clement Adebamowo

Sally N Adebamowo

Keith A Baggerly

Ting-Wen Chen

Hua-Sheng Chiu

Steve Lefever

Liang Liu

Karen MacKenzie

Sandra Orsulic

Jason Roszik

Carl Simon Shelley

Qianqian Song

Christopher P Vellano

Nicolas Wentzensen

John N Weinstein

Gordon B Mills

Douglas A Levine

Rehan Akbani

Affiliations

Soon will be listed here.

Abstract

We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of four gynecological types plus breast. Our aims were to identify shared and unique molecular features, clinically significant subtypes, and potential therapeutic targets. We found 61 somatic copy-number alterations (SCNAs) and 46 significantly mutated genes (SMGs). Eleven SCNAs and 11 SMGs had not been identified in previous TCGA studies of the individual tumor types. We found functionally significant estrogen receptor-regulated long non-coding RNAs (lncRNAs) and gene/lncRNA interaction networks. Pathway analysis identified subtypes with high leukocyte infiltration, raising potential implications for immunotherapy. Using 16 key molecular features, we identified five prognostic subtypes and developed a decision tree that classified patients into the subtypes based on just six features that are assessable in clinical laboratories.

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