Exosomal MicroRNAs As Potential Biomarkers in Neuropsychiatric Disorders

Overview

Journal Methods Mol Biol

Specialty Molecular Biology

Date 2018 Feb 14

PMID 29435924

Citations 13

Authors

Gabriel R Fries

Joao Quevedo

Affiliations

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Abstract

This chapter will discuss the potential use of microRNAs, particularly those located in peripherally-isolated exosomes, as biomarkers in neuropsychiatric disorders. These extracellular vesicles are released as a form of cell-to-cell communication and may mediate the soma-to-germline transmission of brain-relevant information, thereby potentially contributing to the inter- or transgenerational transmission of behavioral traits. Recent novel methods allow for the enrichment of peripheral exosomes specifically released by neurons and astrocytes and may provide valuable brain-relevant biosignatures of disease.

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