Contextual Control of Skin Immunity and Inflammation by

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2018 Feb 1

PMID 29382696

Citations 97

Authors

Vanessa K Ridaura

Nicolas Bouladoux

Jan Claesen

Y Erin Chen

Allyson L Byrd

Michael G Constantinides

Eric D Merrill

Samira Tamoutounour

Michael A Fischbach

Yasmine Belkaid

Affiliations

Soon will be listed here.

Abstract

How defined microbes influence the skin immune system remains poorly understood. Here we demonstrate that , dominant members of the skin microbiota, promote a dramatic increase in the number and activation of a defined subset of γδ T cells. This effect is long-lasting, occurs independently of other microbes, and is, in part, mediated by interleukin (IL)-23. Under steady-state conditions, the impact of is discrete and noninflammatory. However, when applied to the skin of a host fed a high-fat diet, alone promotes inflammation in an IL-23-dependent manner. Such effect is highly conserved among species of and dependent on the expression of a dominant component of the cell envelope, mycolic acid. Our data uncover a mode of communication between the immune system and a dominant genus of the skin microbiota and reveal that the functional impact of canonical skin microbial determinants is contextually controlled by the inflammatory and metabolic state of the host.

Citing Articles

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