Michael A Fischbach
Overview
Explore the profile of Michael A Fischbach including associated specialties, affiliations and a list of published articles.
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Articles
140
Citations
22593
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Recent Articles
1.
Gribonika I, Band V, Chi L, Perez-Chaparro P, Link V, Ansaldo E, et al.
Nature
. 2025 Feb;
639(8053):E6.
PMID: 39972149
No abstract available.
2.
Carter M, Zeng X, Ward C, Landry M, Perelman D, Hennings T, et al.
medRxiv
. 2025 Jan;
PMID: 39830242
Metabolic diseases including type 2 diabetes and obesity pose a significant global health burden. Plant-based diets, including vegan diets, are linked to favorable metabolic outcomes, yet the underlying mechanisms remain...
3.
Bousbaine D, Bauman K, Chen Y, Lalgudi P, Nguyen T, Swenson J, et al.
Nature
. 2024 Dec;
638(8052):1054-1064.
PMID: 39662508
The ubiquitous skin colonist Staphylococcus epidermidis elicits a CD8 T cell response pre-emptively, in the absence of an infection. However, the scope and purpose of this anticommensal immune programme are...
4.
Gribonika I, Band V, Chi L, Perez-Chaparro P, Link V, Ansaldo E, et al.
Nature
. 2024 Dec;
638(8052):1043-1053.
PMID: 39662506
The microbiota colonizes each barrier site and broadly controls host physiology. However, when uncontrolled, microbial colonists can also promote inflammation and induce systemic infection. The unique strategies used at each...
5.
Wei W, Lyu X, Markhard A, Fu S, Mardjuki R, Cavanagh P, et al.
Nature
. 2024 Aug;
633(8028):182-188.
PMID: 39112712
Taurine is a conditionally essential micronutrient and one of the most abundant amino acids in humans. In endogenous taurine metabolism, dedicated enzymes are involved in the biosynthesis of taurine from...
6.
Saha P, Gogonea V, Sweet W, Mohan M, Singh K, Anderson J, et al.
Nat Commun
. 2024 Aug;
15(1):6696.
PMID: 39107277
Allosteric modulation is a central mechanism for metabolic regulation but has yet to be described for a gut microbiota-host interaction. Phenylacetylglutamine (PAGln), a gut microbiota-derived metabolite, has previously been clinically...
7.
Blum J, Kong R, Schulman E, Chen F, Upadhyay R, Romero-Meza G, et al.
bioRxiv
. 2024 Jun;
PMID: 38853977
Food antigens elicit immune tolerance through the action of regulatory T cells (Tregs) in the intestine. Although antigens that trigger common food allergies are known, the epitopes that mediate tolerance...
8.
Wahlstrom A, Brumbaugh A, Sjoland W, Olsson L, Wu H, Henricsson M, et al.
Nat Commun
. 2024 May;
15(1):4276.
PMID: 38769296
Alterations in gut microbiota composition are suggested to contribute to cardiometabolic diseases, in part by producing bioactive molecules. Some of the metabolites are produced by very low abundant bacterial taxa,...
9.
Choucair I, Mallela D, Hilser J, Hartiala J, Nemet I, Gogonea V, et al.
Diabetes
. 2024 May;
73(8):1215-1228.
PMID: 38701355
Article Highlights:
10.
Fischbach M
Cell
. 2024 Apr;
187(8):1828-1833.
PMID: 38608651
Scientists and engineers often spend days choosing a problem and years solving it. This imbalance limits impact. Here, we offer a framework for problem choice: prompts for ideation, guidelines for...