Rhodium-catalyzed C-H Functionalization-based Approach to Eight-membered Lactams

Overview

Journal Chem Sci

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2018 Jan 9

PMID 29308141

Citations 13

Authors

Shangze Wu

Rong Zeng

Chunling Fu

Yihua Yu

Xue Zhang

Shengming Ma

Affiliations

Soon will be listed here.

Abstract

A Rh(iii) catalyzed formal [4 + 2 + 2] cyclization of -pivaloyloxybenzamides with 1,6-allene-enes by C-H functionalization is reported. The reactions occur at room temperature and are compatible with air and moisture with a tolerance of many synthetically useful functional groups. The follow-up modifications of the products have been demonstrated. After careful mechanistic studies and DFT calculation, a reaction mechanism was proposed.

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