Profiling the Lymphoid-resident T Cell Pool Reveals Modulation by Age and Microbiota

Overview

Journal Nat Commun

Specialty Biology

Date 2018 Jan 6

PMID 29302034

Citations 17

Authors

Aurelie Durand

Alexandra Audemard-Verger

Vincent Guichard

Raphael Mattiuz

Arnaud Delpoux

Pauline Hamon

Nelly Bonilla

Matthieu Riviere

Jerome Delon

Bruno Martin

Cedric Auffray

Alexandre Boissonnas

Bruno Lucas

Affiliations

Soon will be listed here.

Abstract

Despite being implicated in non-lymphoid tissues, non-recirculating T cells may also exist in secondary lymphoid organs (SLO). However, a detailed characterization of this lymphoid-resident T cell pool has not yet been done. Here we show that a substantial proportion of CD4 regulatory (Treg) and memory (Tmem) cells establish long-term residence in the SLOs of specific pathogen-free mice. Of these SLOs, only T cell residence within Peyer's patches is affected by microbiota. Resident CD4 Treg and CD4 Tmem cells from lymph nodes and non-lymphoid tissues share many phenotypic and functional characteristics. The percentage of resident T cells in SLOs increases considerably with age, with S1PR1 downregulation possibly contributing to this altered homeostasis. Our results thus show that T cell residence is not only a hallmark of non-lymphoid tissues, but can be extended to secondary lymphoid organs.

Citing Articles

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