Keeping T Cell Memories in Mind

Overview

Journal Trends Immunol

Specialty Allergy & Immunology

Date 2022 Nov 11

PMID 36369103

Authors

Madison R Mix

John T Harty

Affiliations

Soon will be listed here.

Abstract

The mammalian central nervous system (CNS) contains a vibrant community of resident adaptive immune cells at homeostasis. Among these are memory CD8 and CD4 T cells, which reside in the CNS in the settings of health, aging, and neurological disease. These T cells commonly exhibit a tissue-resident memory (T) phenotype, suggesting that they are antigen-experienced and remain separate from the circulation. Despite these characterizations, T cell surveillance of the CNS has only recently been studied through the lens of T immunology. In this Review, we outline emerging concepts of CNS T generation, localization, maintenance, function, and specificity. In this way, we hope to highlight roles of CNS T in health and disease to inform future studies of adaptive neuroimmunity.

Citing Articles

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