Alexander R van Vliet
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Explore the profile of Alexander R van Vliet including associated specialties, affiliations and a list of published articles.
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22
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1582
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Recent Articles
1.
van Vliet A, Jefferies H, Faull P, Chadwick J, Ibrahim F, Skehel M, et al.
J Cell Sci
. 2024 Jan;
137(4).
PMID: 38294121
ATG9A, a transmembrane protein of the core autophagy pathway, cycles between the Golgi, endosomes and a vesicular compartment. ATG9A was recently shown to act as a lipid scramblase, and this...
2.
Chiduza G, Garza-Garcia A, Almacellas E, De Tito S, Pye V, van Vliet A, et al.
Autophagy
. 2023 Nov;
20(3):557-576.
PMID: 37938170
Macroautophagy/autophagy is a fundamental aspect of eukaryotic biology, and the autophay-related protein ATG9A is part of the core machinery facilitating this process. In addition to ATG9A vertebrates encode ATG9B, a...
3.
van Vliet A, De Tito S, Almacellas E, Tooze S
J Vis Exp
. 2023 Jul;
(196).
PMID: 37395569
Autophagy is a highly conserved pathway that the cell uses to maintain homeostasis, degrade damaged organelles, combat invading pathogens, and survive pathological conditions. A set of proteins, called ATG proteins,...
4.
Sassano M, Derua R, Waelkens E, Agostinis P, van Vliet A
Contact (Thousand Oaks)
. 2023 Jun;
4:25152564211052392.
PMID: 37366380
We recently reported that the ER stress kinase PERK regulates ER-mitochondria appositions and ER- plasma membrane (ER-PM) contact sites, independent of its canonical role in the unfolded protein response. PERK...
5.
Sassano M, van Vliet A, Vervoort E, Van Eygen S, Van den Haute C, Pavie B, et al.
J Cell Biol
. 2023 Feb;
222(3).
PMID: 36821088
The integrity of ER-mitochondria appositions ensures transfer of ions and phospholipids (PLs) between these organelles and exerts crucial effects on mitochondrial bioenergetics. Malfunctions within the ER-mitochondria contacts altering lipid trafficking...
6.
van Vliet A, Chiduza G, Maslen S, Pye V, Joshi D, De Tito S, et al.
Mol Cell
. 2022 Nov;
82(22):4324-4339.e8.
PMID: 36347259
ATG9A and ATG2A are essential core members of the autophagy machinery. ATG9A is a lipid scramblase that allows equilibration of lipids across a membrane bilayer, whereas ATG2A facilitates lipid flow...
7.
De Tito S, Hervas J, van Vliet A, Tooze S
Trends Biochem Sci
. 2020 Apr;
45(6):484-496.
PMID: 32307224
Autophagy is traditionally depicted as a signaling cascade that culminates in the formation of an autophagosome that degrades cellular cargo. However, recent studies have identified myriad pathways and cellular organelles...
8.
Carreras-Sureda A, Jana F, Urra H, Durand S, Mortenson D, Sagredo A, et al.
Nat Cell Biol
. 2019 Jun;
21(7):913.
PMID: 31201389
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
9.
Carreras-Sureda A, Jana F, Urra H, Durand S, Mortenson D, Sagredo A, et al.
Nat Cell Biol
. 2019 May;
21(6):755-767.
PMID: 31110288
Mitochondria-associated membranes (MAMs) are central microdomains that fine-tune bioenergetics by the local transfer of calcium from the endoplasmic reticulum to the mitochondrial matrix. Here, we report an unexpected function of...
10.
van Vliet A, Agostinis P
Oncotarget
. 2018 Jan;
8(63):106155-106156.
PMID: 29290929
No abstract available.