David B Iaea
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Explore the profile of David B Iaea including associated specialties, affiliations and a list of published articles.
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192
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Recent Articles
1.
Iaea D, Spahr Z, Singh R, Chan R, Zhou B, Bareja R, et al.
Biochim Biophys Acta Mol Cell Biol Lipids
. 2020 Jan;
1865(4):158609.
PMID: 31917335
STARD4, a member of the evolutionarily conserved START gene family, is a soluble sterol transport protein implicated in cholesterol sensing and maintenance of cellular homeostasis. STARD4 is widely expressed and...
2.
Gao X, De Maziere A, Iaea D, Arthur C, Klumperman J, Ciferri C, et al.
Sci Rep
. 2019 May;
9(1):6907.
PMID: 31061420
Cystine-knot peptides are attractive templates in drug discovery due to a number of features they possess including their 3D conformation, physicochemical stability and synthetic tractability. Yet, their cellular uptake mechanisms...
3.
Iaea D, Maxfield F
PLoS One
. 2017 Nov;
12(11):e0188041.
PMID: 29125865
The cholesterol content of membranes plays an important role in organizing membranes for signal transduction and protein trafficking as well as in modulating the biophysical properties of membranes. While the...
4.
Stefan C, Trimble W, Grinstein S, Drin G, Reinisch K, De Camilli P, et al.
BMC Biol
. 2017 Nov;
15(1):102.
PMID: 29089042
Discoveries spanning several decades have pointed to vital membrane lipid trafficking pathways involving both vesicular and non-vesicular carriers. But the relative contributions for distinct membrane delivery pathways in cell growth...
5.
Jena P, Roxbury D, Galassi T, Akkari L, Horoszko C, Iaea D, et al.
ACS Nano
. 2017 Sep;
11(11):10689-10703.
PMID: 28898055
Lipid accumulation within the lumen of endolysosomal vesicles is observed in various pathologies including atherosclerosis, liver disease, neurological disorders, lysosomal storage disorders, and cancer. Current methods cannot measure lipid flux...
6.
Iaea D, Mao S, Lund F, Maxfield F
Mol Biol Cell
. 2017 Feb;
28(8):1111-1122.
PMID: 28209730
Cholesterol is an essential constituent of membranes in mammalian cells. The plasma membrane and the endocytic recycling compartment (ERC) are both highly enriched in cholesterol. The abundance and distribution of...
7.
Maxfield F, Iaea D, Pipalia N
Biochem Cell Biol
. 2016 Jul;
94(6):499-506.
PMID: 27421092
Cholesterol plays an important role in determining the biophysical properties of membranes in mammalian cells, and the concentration of cholesterol in membranes is tightly regulated. Cholesterol moves among membrane organelles...
8.
A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol
Iaea D, Gale S, Bielska A, Krishnan K, Fujiwara H, Jiang H, et al.
J Lipid Res
. 2015 Oct;
56(12):2408-19.
PMID: 26497473
Cholesterol homeostasis is regulated not only by cholesterol, but also by oxygenated cholesterol species, referred to as oxysterols. Side-chain oxysterols, such as 25-hydroxycholesterol (25-HC), regulate cholesterol homeostasis through feedback inhibition...
9.
Iaea D, Dikiy I, Kiburu I, Eliezer D, Maxfield F
Biochemistry
. 2015 Jul;
54(30):4623-36.
PMID: 26168008
The steroidogenic acute regulatory protein-related lipid transfer (START) domain family is defined by a conserved 210-amino acid sequence that folds into an α/β helix-grip structure. Members of this protein family...
10.
Iaea D, Maxfield F
Essays Biochem
. 2015 Feb;
57:43-55.
PMID: 25658343
Sterols are a critical component of cell membranes of eukaryotes. In mammalian cells there is approximately a six-fold range in the cholesterol content in various organelles. The cholesterol content of...