Biology and Mechanisms of Action of the Vitamin D Hormone

Overview

Journal Endocrinol Metab Clin North Am

Publisher Elsevier

Specialty Endocrinology

Date 2017 Oct 30

PMID 29080638

Citations 126

Authors

J Wesley Pike

Sylvia Christakos

Affiliations

Soon will be listed here.

Abstract

The central role of hormonal 1,25-dihydroxyvitamin D [1,25(OH)D] is to regulate calcium and phosphorus homeostasis via actions in intestine, kidney, and bone. These and other actions in many cell types not involved in mineral metabolism are mediated by the vitamin D receptor. Recent studies using genome-wide scale techniques have extended fundamental ideas regarding vitamin D-mediated control of gene expression while simultaneously revealing a series of new concepts. This article summarizes the current view of the biological actions of the vitamin D hormone and focuses on new concepts that drive the understanding of the mechanisms through which vitamin D operates.

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