DNA Sequencing at 40: Past, Present and Future

Overview

Journal Nature

Specialty Science

Date 2017 Oct 12

PMID 29019985

Citations 323

Authors

Jay Shendure

Shankar Balasubramanian

George M Church

Walter Gilbert

Jane Rogers

Jeffery A Schloss

Robert H Waterston

Affiliations

Soon will be listed here.

Abstract

This review commemorates the 40th anniversary of DNA sequencing, a period in which we have already witnessed multiple technological revolutions and a growth in scale from a few kilobases to the first human genome, and now to millions of human and a myriad of other genomes. DNA sequencing has been extensively and creatively repurposed, including as a 'counter' for a vast range of molecular phenomena. We predict that in the long view of history, the impact of DNA sequencing will be on a par with that of the microscope.

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