Wnt Signalling Pathways in Chronic Lymphocytic Leukaemia and B-cell Lymphomas

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 2017 Jul 14

PMID 28703283

Citations 36

Authors

Pavlina Janovska

Vitezslav Bryja

Affiliations

Soon will be listed here.

Abstract

Linked Articles: This article is part of a themed section on WNT Signalling: Mechanisms and Therapeutic Opportunities. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.24/issuetoc.

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References

Yuseff M, Lennon-Dumenil A . B Cells use Conserved Polarity Cues to Regulate Their Antigen Processing and Presentation Functions. Front Immunol. 2015; 6:251. PMC: 4445385. DOI: 10.3389/fimmu.2015.00251. View

Delgado J, Doubek M, Baumann T, Kotaskova J, Molica S, Mozas P . Chronic lymphocytic leukemia: A prognostic model comprising only two biomarkers (IGHV mutational status and FISH cytogenetics) separates patients with different outcome and simplifies the CLL-IPI. Am J Hematol. 2017; 92(4):375-380. DOI: 10.1002/ajh.24660. View

Mahadevan D, Choi J, Cooke L, Simons B, Riley C, Klinkhammer T . Gene Expression and Serum Cytokine Profiling of Low Stage CLL Identify WNT/PCP, Flt-3L/Flt-3 and CXCL9/CXCR3 as Regulators of Cell Proliferation, Survival and Migration. Hum Genomics Proteomics. 2010; 2009:453634. PMC: 2958625. DOI: 10.4061/2009/453634. View

Parameswaran N, Matsui K, Gupta N . Conformational switching in ezrin regulates morphological and cytoskeletal changes required for B cell chemotaxis. J Immunol. 2011; 186(7):4088-97. PMC: 3106416. DOI: 10.4049/jimmunol.1001139. View

Seifert J, Mlodzik M . Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility. Nat Rev Genet. 2007; 8(2):126-38. DOI: 10.1038/nrg2042. View

Clevers H . Wnt/beta-catenin signaling in development and disease. Cell. 2006; 127(3):469-80. DOI: 10.1016/j.cell.2006.10.018. View

Linke F, Harenberg M, Nietert M, Zaunig S, von Bonin F, Arlt A . Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma. Leukemia. 2016; 31(2):361-372. DOI: 10.1038/leu.2016.232. View

Hudecek M, Schmitt T, Baskar S, Lupo-Stanghellini M, Nishida T, Yamamoto T . The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor. Blood. 2010; 116(22):4532-41. PMC: 2996114. DOI: 10.1182/blood-2010-05-283309. View

Widhopf 2nd G, Cui B, Ghia E, Chen L, Messer K, Shen Z . ROR1 can interact with TCL1 and enhance leukemogenesis in Eμ-TCL1 transgenic mice. Proc Natl Acad Sci U S A. 2014; 111(2):793-8. PMC: 3896194. DOI: 10.1073/pnas.1308374111. View

10.

Lazarian G, Guieze R, Wu C . Clinical Implications of Novel Genomic Discoveries in Chronic Lymphocytic Leukemia. J Clin Oncol. 2017; 35(9):984-993. PMC: 5559883. DOI: 10.1200/JCO.2016.71.0822. View

11.

Luis T, Ichii M, Brugman M, Kincade P, Staal F . Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development. Leukemia. 2011; 26(3):414-21. PMC: 3378318. DOI: 10.1038/leu.2011.387. View

12.

Semenov M, Habas R, MacDonald B, He X . SnapShot: Noncanonical Wnt Signaling Pathways. Cell. 2007; 131(7):1378. DOI: 10.1016/j.cell.2007.12.011. View

13.

Burger J, Landau D, Taylor-Weiner A, Bozic I, Zhang H, Sarosiek K . Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition. Nat Commun. 2016; 7:11589. PMC: 4876453. DOI: 10.1038/ncomms11589. View

14.

Kestler H, Kuhl M . From individual Wnt pathways towards a Wnt signalling network. Philos Trans R Soc Lond B Biol Sci. 2008; 363(1495):1333-47. PMC: 2610122. DOI: 10.1098/rstb.2007.2251. View

15.

Memarian A, Hojjat-Farsangi M, Asgarian-Omran H, Younesi V, Jeddi-Tehrani M, Sharifian R . Variation in WNT genes expression in different subtypes of chronic lymphocytic leukemia. Leuk Lymphoma. 2009; 50(12):2061-70. DOI: 10.3109/10428190903331082. View

16.

Alexander S, Fabbro D, Kelly E, Marrion N, Peters J, Benson H . The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors. Br J Pharmacol. 2015; 172(24):5979-6023. PMC: 4718208. DOI: 10.1111/bph.13353. View

17.

Bichi R, Shinton S, Martin E, Koval A, Calin G, Cesari R . Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. Proc Natl Acad Sci U S A. 2002; 99(10):6955-60. PMC: 124510. DOI: 10.1073/pnas.102181599. View

18.

Wu W, Zhu H, Fu Y, Shen W, Miao K, Hong M . High LEF1 expression predicts adverse prognosis in chronic lymphocytic leukemia and may be targeted by ethacrynic acid. Oncotarget. 2016; 7(16):21631-43. PMC: 5008311. DOI: 10.18632/oncotarget.7795. View

19.

Hofbauer S, Krenn P, Ganghammer S, Asslaber D, Pichler U, Oberascher K . Tiam1/Rac1 signals contribute to the proliferation and chemoresistance, but not motility, of chronic lymphocytic leukemia cells. Blood. 2014; 123(14):2181-8. DOI: 10.1182/blood-2013-08-523563. View

20.

Wang L, Lawrence M, Wan Y, Stojanov P, Sougnez C, Stevenson K . SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med. 2011; 365(26):2497-506. PMC: 3685413. DOI: 10.1056/NEJMoa1109016. View