Wnt/beta-catenin Signaling in Development and Disease

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2006 Nov 4

PMID 17081971

Citations 2761

Authors

Hans Clevers

Affiliations

Soon will be listed here.

Abstract

A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades. Wnt genes encode small secreted proteins that are found in all animal genomes. Wnt signaling is involved in virtually every aspect of embryonic development and also controls homeostatic self-renewal in a number of adult tissues. Germline mutations in the Wnt pathway cause several hereditary diseases, and somatic mutations are associated with cancer of the intestine and a variety of other tissues.

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