Spray Stability of Self-assembled Filaments for Delivery

Overview

Journal J Control Release

Specialty Pharmacology

Date 2017 May 28

PMID 28549950

Citations 2

Authors

Abdullah Mahmud

Takamasa Harada

Karthikan Rajagopal

David A Christian

Praful Nair

Ryan Murphy

Dennis E Discher

Affiliations

Soon will be listed here.

Abstract

Filamentous viruses are common in nature and efficiently deliver - sometimes via aerosol - genetic material, viral proteins, and other factors to animals and plants. Aerosolization can be a severe physicochemical test of the stability of any filamentous assembly whether it is made from natural polymers such as viral proteins or synthetic polymers. Here, worm-like "filomicelles" that self-assemble in water from amphiphilic block copolymers were investigated as aerosolized delivery vehicles. After spraying and drying, fluorophore-loaded filomicelles that were originally ~10-20μm long could be imaged as 2-5μm long fragments that survived rehydration on natural and artificial surfaces (i.e. plant leaves and glass). As a functional test of delivery, the hydrophobic pesticide bifenthrin was loaded into filomicelles (up to 25% w/w) and sprayed onto plants infested with two agricultural pests, beet army worm or two-spotted spider mites; pesticidal efficacy exceeded that of commercial formulations. Persistent delivery by the filomicelle formulation was especially notable and broadly consistent with previous intravenous delivery of other drugs and dyes with the highly elongated filomicelles.

Citing Articles

Collagen-Binding Peptide-Enabled Supramolecular Hydrogel Design for Improved Organ Adhesion and Sprayable Therapeutic Delivery.

Anderson C, Chakroun R, Grimmett M, Domalewski C, Wang F, Cui H Nano Lett. 2022; 22(10):4182-4191.

PMID: 35522052 PMC: 9844543. DOI: 10.1021/acs.nanolett.2c00967.

Interface-Enrichment-Induced Instability and Drug-Loading-Enhanced Stability in Inhalable Delivery of Supramolecular Filaments.

Anderson C, Chakroun R, Su H, Mitrut R, Cui H ACS Nano. 2019; 13(11):12957-12968.

PMID: 31651153 PMC: 7043235. DOI: 10.1021/acsnano.9b05556.

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