Karthikan Rajagopal
Overview
Explore the profile of Karthikan Rajagopal including associated specialties, affiliations and a list of published articles.
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32
Citations
1178
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Recent Articles
1.
Nayak P, Rajagopal K, Chang D
Eur J Pharm Biopharm
. 2022 Aug;
178:105-116.
PMID: 35917864
The ability to deliver stable and active dried protein therapeutics from biopharmaceutical drug delivery systems is critical for solid dosage formulation development. Spray dried formulations with carefully selected excipients provide...
2.
Koshari S, Shi X, Jiang L, Chang D, Rajagopal K, Lenhoff A, et al.
J Pharm Sci
. 2021 Sep;
111(2):345-357.
PMID: 34516986
An extensive data set has been developed and used to further the progress of a model-informed design of controlled drug release. An improved drug-release model with mechanistic modeling of hydrolytic...
3.
Nagapudi K, Zhu A, Chang D, Lomeo J, Rajagopal K, Hannoush R, et al.
J Pharm Sci
. 2021 Jun;
110(10):3418-3430.
PMID: 34089709
Long-acting implants are typically formulated using carrier(s) with specific physical and chemical properties, along with the active pharmaceutical ingredient (API), to achieve the desired daily exposure for the target duration...
4.
Chang D, Burra S, Day E, Chan J, Comps-Agrar L, Nivaggioli T, et al.
J Pharm Sci
. 2020 Oct;
110(2):860-870.
PMID: 33031788
The port delivery system with ranibizumab (PDS) is an investigational long-acting drug delivery system for the continuous release of ranibizumab, an anti-VEGF biologic, in the vitreous humor. The efficacy of...
5.
Nayak P, Goode M, Chang D, Rajagopal K
Mol Pharm
. 2020 Jul;
17(9):3291-3297.
PMID: 32672979
Maintenance of protein stability during manufacture, storage, and delivery is necessary for the successful development of a drug product. Herein, the utility of two compatible solutes-ectoine and hydroxyectoine-in stabilizing a...
6.
Mantha N, Burra S, Rajagopal K, Sreedhara A
Pharm Res
. 2020 Apr;
37(5):85.
PMID: 32337641
Purpose: To evaluate the stability of a model Mab1 and Fab1 under in vitro vitreal conditions in the presence of various metabolites and in the presence of light at λ ...
7.
Sancho Oltra N, Swift J, Mahmud A, Rajagopal K, Loverde S, Discher D
J Mater Chem B
. 2020 Apr;
1(39):5177-5185.
PMID: 32263324
Nanoparticles that are made by self-assembly into non-spherical shapes are promising as drug delivery vehicles. This review focuses on flexible and fragmentable filamentous micelles referred to as filomicelles made of...
8.
Famili A, Crowell S, Loyet K, Mandikian D, Boswell C, Cain D, et al.
Bioconjug Chem
. 2019 Sep;
30(11):2782-2789.
PMID: 31553572
Treatment of ocular diseases associated with neovascularization currently requires frequent intravitreal injections of antivascular endothelial growth factor (anti-VEGF) therapies. Reducing the required frequency of anti-VEGF injections and associated clinical visits...
9.
Koshari S, Chang D, Wang N, E Zarraga I, Rajagopal K, Lenhoff A, et al.
J Pharm Sci
. 2019 Jul;
108(11):3582-3591.
PMID: 31278916
Mathematical modeling of drug release can aid in the design and development of sustained delivery systems, but the parameter estimation of such models is challenging owing to the nonlinear mathematical...
10.
Rajagopal K, Chang D, Nayak P, Izadi S, Patapoff T, Zhang J, et al.
Mol Pharm
. 2018 Dec;
16(1):349-358.
PMID: 30525659
The preparation of PLGA rods for sustained release applications via a hot-melt extrusion process employs heat and mechanical shear. Understanding protein stability and degradation mechanisms at high temperature in the...