Fucoxanthin Prevents HO-induced Neuronal Apoptosis Via Concurrently Activating the PI3-K/Akt Cascade and Inhibiting the ERK Pathway

Overview

Journal Food Nutr Res

Specialty Nutritional Sciences

Date 2017 May 5

PMID 28469544

Citations 27

Authors

Jie Yu

Jia-Jia Lin

Rui Yu

Shan He

Qin-Wen Wang

Wei Cui

Jin-Rong Zhang

Affiliations

Soon will be listed here.

Abstract

: As a natural carotenoid abundant in chloroplasts of edible brown algae, fucoxanthin possesses various health benefits, including anti-oxidative activity in particular. : In the present study, we studied whether fucoxanthin protected against hydrogen peroxide (HO)-induced neuronal apoptosis. : The neuroprotective effects of fucoxanthin on HO-induced toxicity were studied in both SH-SY5Y cells and primary cerebellar granule neurons. : Fucoxanthin significantly protected against HO-induced neuronal apoptosis and intracellular reactive oxygen species. HO treatment led to the reduced activity of phosphoinositide 3-kinase (PI3-K)/Akt cascade and the increased activity of extracellular signal-regulated kinase (ERK) pathway in SH-SY5Y cells. Moreover, fucoxanthin significantly restored the altered activities of PI3-K/Akt and ERK pathways induced by HO. Both specific inhibitors of glycogen synthase kinase 3β (GSK3β) and mitogen-activated protein kinase kinase (MEK) significantly protected against HO-induced neuronal death. Furthermore, the neuroprotective effects of fucoxanthin against HO-induced neuronal death were abolished by specific PI3-K inhibitors. : Our data strongly revealed that fucoxanthin protected against HO-induced neurotoxicity via concurrently activating the PI3-K/Akt cascade and inhibiting the ERK pathway, providing support for the use of fucoxanthin to treat neurodegenerative disorders induced by oxidative stress.

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