Carotenoids As Modulators of the PI3K/Akt/mTOR Pathway: Innovative Strategies in Cancer Therapy

Overview

Journal Med Oncol

Publisher Springer

Specialty Oncology

Date 2024 Nov 16

PMID 39549201

Authors

Biswajit Kumar Utpal

Zerrouki Dehbia

B M Redwan Matin Zidan

Sherouk Hussein Sweilam

Laliteshwar Pratap Singh

M S Arunkumar

M Sona

Uttam Prasad Panigrahy

R Keerthana

Sandhya Rani Mandadi

Safia Obaidur Rab

Mohammed Ali Alshehri

Doukani Koula

Muath Suliman

Mohamed H Nafady

Talha Bin Emran

Affiliations

Soon will be listed here.

Abstract

Cancer progression is primarily driven by the uncontrolled activation of cellular signaling pathways, with the PI3K/Akt/mTOR (PAMT) pathway playing a central role. This pathway significantly contributes to the proliferation and survival of cancer cells, and its hyperactivity is a major challenge in managing several types of malignancies. This article delves into the promising potential of carotenoids, natural pigments found in abundance in fruits and vegetables, as a novel therapeutic strategy for cancer treatment. By specifically targeting and inhibiting the PAMT pathway, carotenoids may effectively disrupt the growth and survival of cancer cells. The article examines the complex mechanisms underlying these interactions and highlights the obstacles faced in cancer treatment. It proposes a compelling approach to developing therapies that leverage natural products to target this critical pathway, offering a fresh perspective on cancer treatment. Further research is essential to enhance the therapeutic efficacy of these compounds.

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