Bladder Cancer: Micro RNAs As Biomolecules for Prognostication and Surveillance

Overview

Journal Indian J Urol

Specialty Urology

Date 2017 May 5

PMID 28469300

Citations 12

Authors

Nilay Mitash

Swasti Tiwari

Shalini Agnihotri

Anil Mandhani

Affiliations

Soon will be listed here.

Abstract

Introduction: Bladder cancer (BC) has varied clinical behavior in terms of recurrence and progression. Current pathological characteristics are insufficient to prognosticate the outcome of a given treatment. Cellular metabolic regulatory molecules, such as micro RNA (miRNA), could be a potential biomarker to prognosticate the treatment outcomes.

Materials And Methods: PubMed and Google Scholar databases were searched for publications from 1990 to 2016, related to miRNA biogenesis, its function, and role in the pathogenesis of bladder as well as other cancers. Articles were searched using MeSH terms micrornas, micrornas AND neoplasm, and micrornas AND urinary bladder neoplasm. Out of the 108 publications reviewed 75 references were selected based on the clinical relevance. Articles were reviewed to assess the role of miRNA in various cancers and those in BC as a diagnostic or therapeutic tool.

Results: More than 35 miRNAs were found to be associated with different pathways of cellular dedifferentiation, proliferation, and progression of BC as well as other cancers. A normal looking mucosa may show molecular changes preceding phenotypic changes in the form of varied expression of miR-129, miR-200a, and miR-205. miR-214, miR-99a, and miR-125b have been shown to be potential urinary biomarkers of BC. miRNAs could act as a repressor for protein molecule functioning or activator of different pathways to be used as a therapeutic target too.

Conclusions: Despite certain limitations, such as instability, rapid plasma clearance, and targeting antagonist proteins of cellular metabolic pathways, miRNAs have potential to be studied as a biomarker or a therapeutic target for BC.

Citing Articles

An Overview of Angiogenesis in Bladder Cancer.

Elayat G, Punev I, Selim A Curr Oncol Rep. 2023; 25(7):709-728.

PMID: 37052868 PMC: 10256644. DOI: 10.1007/s11912-023-01421-5.

Non-coding RNA and autophagy: Finding novel ways to improve the diagnostic management of bladder cancer.

Tantray I, Ojha R, Sharma A Front Genet. 2023; 13:1051762.

PMID: 36685879 PMC: 9845264. DOI: 10.3389/fgene.2022.1051762.

Renal Oncocytoma: The Diagnostic Challenge to Unmask the Double of Renal Cancer.

Trevisani F, Floris M, Minnei R, Cinque A Int J Mol Sci. 2022; 23(5).

PMID: 35269747 PMC: 8910282. DOI: 10.3390/ijms23052603.

MicroRNA-300 Inhibits the Proliferation and Metastasis of Cervical Cancer Cells via Posttranscriptional Suppression of G Protein-Coupled Receptor 34 (GPR34).

Wang M, Tian Y, Miao L, Zhao W J Oncol. 2021; 2021:2669822.

PMID: 34950207 PMC: 8691979. DOI: 10.1155/2021/2669822.

The Role of MicroRNA in the Airway Surface Liquid Homeostasis.

Mitash N, Donovan J, Swiatecka-Urban A Int J Mol Sci. 2020; 21(11).

PMID: 32481719 PMC: 7312818. DOI: 10.3390/ijms21113848.

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