MicroRNAs and Stem Cells: Control of Pluripotency, Reprogramming, and Lineage Commitment

Overview

Journal Circ Res

Specialty Cardiology & Vascular Diseases

Date 2012 Mar 31

PMID 22461365

Citations 75

Authors

Eva-Marie Heinrich

Stefanie Dimmeler

Affiliations

Soon will be listed here.

Abstract

Stem cells hold great promise for regenerative medicine and the treatment of cardiovascular diseases. The mechanisms regulating self-renewal, pluripotency, and differentiation are not fully understood. MicroRNAs (miRs) are small noncoding RNAs controlling gene expression, either by inducing mRNA degradation or by blocking mRNA translation. The expression of miRs was shown to regulate various aspects of stem cell functions, including the maintenance and induction of pluripotency for reprogramming. In addition, some miRs control cell fate decisions. This review summarizes the role of miRs in reprogramming and embryonic stem cell self-renewal, and specifically addresses the regulation of cardiovascular cell fate decisions by miRs.

Citing Articles

Onco-Ontogeny of Squamous Cell Cancer of the First Pharyngeal Arch Derivatives.

Sat-Munoz D, Balderas-Pena L, Gomez-Sanchez E, Martinez-Herrera B, Trujillo-Hernandez B, Quiroga-Morales L Int J Mol Sci. 2024; 25(18).

PMID: 39337467 PMC: 11432412. DOI: 10.3390/ijms25189979.

Stem Cell-Derived Exosomal MicroRNAs as Novel Potential Approach for Multiple Sclerosis Treatment.

Tahmasebi F, Asl E, Vahidinia Z, Barati S Cell Mol Neurobiol. 2024; 44(1):44.

PMID: 38713302 PMC: 11076329. DOI: 10.1007/s10571-024-01478-1.

ADSC-derived exosomes attenuate myocardial infarction injury by promoting miR-205-mediated cardiac angiogenesis.

Wang T, Li T, Niu X, Hu L, Cheng J, Guo D Biol Direct. 2023; 18(1):6.

PMID: 36849959 PMC: 9972746. DOI: 10.1186/s13062-023-00361-1.

Combined Noncoding RNA-mRNA Regulomics Signature in Reprogramming and Pluripotency in iPSCs.

Salloum-Asfar S, Abdulla S, Taha R, Thompson I, Emara M Cells. 2022; 11(23).

PMID: 36497092 PMC: 9737797. DOI: 10.3390/cells11233833.

LncRNAs and their RBPs: How to influence the fate of stem cells?.

Zhao C, Xie W, Zhu H, Zhao M, Liu W, Wu Z Stem Cell Res Ther. 2022; 13(1):175.

PMID: 35505438 PMC: 9066789. DOI: 10.1186/s13287-022-02851-x.