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Imprinted MicroRNA Genes Transcribed Antisense to a Reciprocally Imprinted Retrotransposon-like Gene

Overview
Journal Nat Genet
Specialty Genetics
Date 2003 Jun 11
PMID 12796779
Citations 140
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Abstract

MicroRNAs (miRNAs) are an abundant class of RNAs that are approximately 21-25 nucleotides (nt) long, interact with mRNAs and trigger either translation repression or RNA cleavage (RNA interference, RNAi) depending on the degree of complementarity with their targets. Here we show that the imprinted mouse distal chromosome 12 locus encodes two miRNA genes expressed from the maternally inherited chromosome and antisense to a retrotransposon-like gene (Rtl1) expressed only from the paternal allele.

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