Orthopaedic Device-related Infection: Current and Future Interventions for Improved Prevention and Treatment

Overview

Journal EFORT Open Rev

Specialty Orthopedics

Date 2017 May 3

PMID 28461934

Citations 74

Authors

T Fintan Moriarty

Richard Kuehl

Tom Coenye

Willem-Jan Metsemakers

Mario Morgenstern

Edward M Schwarz

Martijn Riool

Sebastian A J Zaat

Nina Khana

Stephen L Kates

R Geoff Richards

Affiliations

Soon will be listed here.

Abstract

Orthopaedic and trauma device-related infection (ODRI) remains one of the major complications in modern trauma and orthopaedic surgery.Despite best practice in medical and surgical management, neither prophylaxis nor treatment of ODRI is effective in all cases, leading to infections that negatively impact clinical outcome and significantly increase healthcare expenditure.The following review summarises the microbiological profile of modern ODRI, the impact antibiotic resistance has on treatment outcomes, and some of the principles and weaknesses of the current systemic and local antibiotic delivery strategies.The emerging novel strategies aimed at preventing or treating ODRI will be reviewed. Particular attention will be paid to the potential for clinical impact in the coming decades, when such interventions are likely to be critically important.The review focuses on this problem from an interdisciplinary perspective, including basic science innovations and best practice in infectious disease. Cite this article: Moriarty TF, Kuehl R, Coenye T, et al. Orthopaedic device related infection: current and future interventions for improved prevention and treatment. 2016;1:89-99. DOI: 10.1302/2058-5241.1.000037.

Citing Articles

Evaluation of Antimicrobial Performance of Calcium Dihydroxide (Ca(OH)) Coating on Ti for Potential Metallic Orthopedic Implant Applications.

Holeczek H, de Wild M, Ruegg J, Gruner P, Moser W, Braissant O Antibiotics (Basel). 2025; 14(1).

PMID: 39858376 PMC: 11761600. DOI: 10.3390/antibiotics14010091.

Biofilm morphology and antibiotic susceptibility of methicillin-resistant (MRSA) on poly-D,L-lactide--poly(ethylene glycol) (PDLLA-PEG) coated titanium.

Turner A, Zermeno-Perez D, Mysior M, Giraldo-Osorno P, Garcia B, OGorman E Biofilm. 2025; 8():100228.

PMID: 39830519 PMC: 11740804. DOI: 10.1016/j.bioflm.2024.100228.

Regulatory Standard for Determining Preoperative Skin Preparation Efficacy Underreports True Dermal Bioburden in a Porcine Model.

Duffy H, Ashton N, Blair A, Hooper N, Stulce P, Williams D Microorganisms. 2024; 12(11).

PMID: 39597757 PMC: 11596398. DOI: 10.3390/microorganisms12112369.

Exploring the potential of naturally occurring antimicrobials for managing orthopedic-device-related infections.

Chen B, Moriarty T, Steenackers H, Vles G, Onsea J, Vackier T J Bone Jt Infect. 2024; 9(5):249-260.

PMID: 39539734 PMC: 11555427. DOI: 10.5194/jbji-9-249-2024.

Isolation and Antibiofilm Activity of Bacteriophages against from Patients with Periprosthetic Joint Infection.

Chen B, Chitto M, Tao S, Wagemans J, Lavigne R, Geoff Richards R Viruses. 2024; 16(10).

PMID: 39459925 PMC: 11512206. DOI: 10.3390/v16101592.

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